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首页> 外文期刊>Reproductive toxicology >Effect of in vitro exposure to benzo(a)pyrene, a component of cigarette smoke, on folliculogenesis, steroidogenesis and oocyte nuclear maturation.
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Effect of in vitro exposure to benzo(a)pyrene, a component of cigarette smoke, on folliculogenesis, steroidogenesis and oocyte nuclear maturation.

机译：体外暴露于香烟烟雾中的苯并（a）re对卵泡生成，类固醇生成和卵母细胞核成熟的影响。

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We previoulsy quantified the concentration of benzo[a]pyrene (B[a]P) in the follicular fluid of women exposed to mainstream and/or sidestream cigarette smoke. The objective of this study was to quantify the effects of B[a]P-exposure, at concentrations representative of follicluar fluid concentrations, on folliculogenesis, on gonadal steroid and anti-mullerian hormone (AMH) output, oocyte growth, and nuclear maturation. Follicles (100-130 mum) isolated from ovaries of F1 hybrid (C57BL/6jxCBA/Ca) mice were cultured for 13 days in increasing concentrations of B[a]P (0 ng/ml (control) to 45 ng/ml). B[a]P treatment inhibited (p < 0 .05) antral follicle development, decreased estradiol output and follicle survival at the 45.0 ng/ml dose. B[a]P exposure decreased AMH output overall during preantral (p = 0.014) and antral (p = 0.026) follicle development but had no effect on progesterone output or oocyte growth and nuclear maturation in surviving follicles. These data suggest that B[a]P is an important toxic component of cigarette smoke that adversely affects follicular development and survival.
机译：我们预先量化了暴露于主流和/或侧流香烟烟雾的女性卵泡液中苯并[a]]的浓度。这项研究的目的是量化暴露于卵泡液浓度的B [a] P暴露对卵泡生成，性腺类固醇和抗苗勒激素（AMH）输出，卵母细胞生长和核成熟的影响。从F1杂种小鼠（C57BL / 6jxCBA / Ca）卵巢中分离出的卵泡（100-130 mum）在B [a] P（0 ng / ml（对照）至45 ng / ml）浓度升高的条件下培养13天。 B [a] P治疗在45.0 ng / ml剂量下可抑制（p <0.05）肛门卵泡发育，雌二醇输出减少和卵泡存活。 B [a] P暴露在卵泡发育之前（p = 0.014）和肛门（p = 0.026）期间总体上降低了AMH的产量，但对存活的卵泡中的孕酮产量或卵母细胞生长和核成熟没有影响。这些数据表明，B [a] P是香烟烟雾的重要毒性成分，会对卵泡发育和生存产生不利影响。

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