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首页> 外文期刊>Reproductive toxicology >Paternal treatment with cisplatin impairs reproduction of adult male offspring in rats.
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Paternal treatment with cisplatin impairs reproduction of adult male offspring in rats.

机译：顺铂的父本治疗会损害大鼠成年雄性后代的繁殖。

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This study evaluated the acute and persistent effects of paternal cisplatin-treatment on progeny. Wistar male rats (45 days old) were assigned into 2 groups. Control and cisplatin (CP: 1mg/kg-d, 5 days/week, for 3 weeks, ip.). Male rats at 66 (end of treatment, acute effects evaluation) and 140 days old (after recovery period, persistent effects evaluation) were mated with females. Fetal and post-natal developments of the offspring sired by treated-male mated in both ages were evaluated, including fertility of adult male offspring. No adverse effects in fetal development or puberty onset were seen in CP offspring. However, testicular descent was delayed and postnatal growth was impaired in these animals (acute effect). Moreover, seminal vesicle weight and epididymal sperm count from adult progeny were affected (acute effects) by paternal CP-exposure. The only persistent effect found was alterations in the spermatogenesis. We conclude that paternal CP-administration during peri-puberty affects reproductive endpoints of the progeny.
机译：这项研究评估了父本顺铂治疗对子代的急性和持续性作用。将Wistar雄性大鼠（45天大）分为两组。对照和顺铂（CP：1mg / kg-d，5天/周，持续3周，腹腔注射）。将66岁（治疗结束，急性作用评估）和140天大（恢复期后，持续作用评估）的雄性大鼠与雌性交配。评价了在两个年龄段都已交配的雄性所生的后代的胎儿和产后发育，包括成年雄性后代的生育能力。在CP后代中未观察到对胎儿发育或青春期发作的不利影响。但是，这些动物的睾丸后裔被延迟，产后生长受到损害（急性作用）。此外，父亲CP暴露会影响成年后代的精囊重量和附睾精子计数（急性作用）。发现的唯一持久作用是精子发生的改变。我们得出的结论是，青春期前后的父亲CP给药会影响子代的生殖终点。

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