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首页> 外文期刊>Reproductive toxicology >Prenatal and postnatal exposure to polychlorinated biphenyls and child size at 24 months of age.
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Prenatal and postnatal exposure to polychlorinated biphenyls and child size at 24 months of age.

机译：产前和产后暴露于多氯联苯的情况以及24个月大的儿童的大小。

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Research suggests that exposure to polychlorinated biphenyls (PCBs) may result in decreased child growth, though the critical window(s) are unclear. We investigated the association between PCBs and child size at age 24 months (n=44). PCBs were measured in first trimester serum, breast milk, and child serum at age 24 months, and dichotomized at the median. Age- and gender-specific z-scores were calculated for anthropometric measures. Using linear regression, we observed no significant changes in z-scores with prenatal or postnatal serum PCB concentrations. PCB-77 in breast milk was associated with a significant decrease in z-score for length. To our knowledge, this study is the first to examine child size in relation to PCBs measured early in pregnancy, as well as quantifying a far greater number of congeners. Further research is needed to clarify critical windows, congener-specific effects, and effect modification by sex in relation to PCBs and child anthropometric measures.
机译：研究表明，尽管关键窗口尚不清楚，但接触多氯联苯（PCB）可能会导致儿童生长下降。我们调查了多氯联苯与24个月大的儿童大小之间的关联（n = 44）。在24个月大时，在头三个月的血清，母乳和儿童血清中测量PCBs，并在中位数二等分。计算了针对年龄和性别的z得分，用于人体测量。使用线性回归，我们观察到产前或产后血清PCB浓度与z得分无明显变化。母乳中的PCB-77与Z值评分的明显降低有关。据我们所知，这项研究是第一个检查与怀孕初期测得的多氯联苯有关的儿童人数，并量化大量同类婴儿的研究。需要进一步的研究来阐明关键窗口，特定祖细胞效应以及与多氯联苯和儿童人体测量学有关的性别效应修正。

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