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首页> 外文期刊>Reproductive toxicology >Estrogen receptor alpha overexpressing mouse antral follicles are sensitive to atresia induced by methoxychlor and its metabolites
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Estrogen receptor alpha overexpressing mouse antral follicles are sensitive to atresia induced by methoxychlor and its metabolites

机译：雌激素受体α过表达的小鼠肛门卵泡对甲氧氯及其代谢物引起的闭锁敏感

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摘要

Methoxychlor (MXC) and its metabolites bind to estrogen receptors (ESRs) and increase ovarian atresia. To test whether ESR alpha (ESR1) overexpressing (ESR1 OE) antral follicles are more sensitive to atresia compared to controls, we cultured antral follicles with vehicle, MXC (1-100. μg/ml) or metabolites (0.1-10. μg/ml). Results indicate that MXC and its metabolites significantly increase atresia in ESR1 OE antral follicles at lower doses compared to controls. Activity of pro-apoptotic factor caspase-3/7 was significantly higher in ESR1 OE treated antral follicles compared to controls. ESR1 OE mice dosed with MXC 64. mg/kg/day had an increased percentage of atretic antral follicles compared to controls. Furthermore, pro-caspase-3 levels were found to be significantly lower in ESR1 OE ovaries than controls dosed with MXC 64. mg/kg/day. These data suggest that ESR1 OE ovaries are more sensitive to atresia induced by MXC and its metabolites . in vitro and . in vivo compared to controls.
机译：甲氧氯（MXC）及其代谢物与雌激素受体（ESR）结合并增加卵巢闭锁。为了测试与对照相比，ESRα（ESR1）过表达（ESR1 OE）窦卵泡对闭锁更敏感，我们用媒介物，MXC（1-100。μg/ ml）或代谢产物（0.1-10。μg/ ml）培养了肛门卵泡。毫升）。结果表明，与对照组相比，MXC及其代谢物以较低的剂量显着增加了ESR1 OE窦房滤泡的闭锁。与对照组相比，ESR1 OE处理的肛门卵泡中促凋亡因子caspase-3 / 7的活性明显更高。与对照组相比，每天以MXC 64. mg / kg /天给药的ESR1 OE小鼠的闭角窦毛囊百分比增加。此外，发现ESR1 OE卵巢中的半胱天冬酶原3水平显着低于以MXC 64. mg / kg /天给药的对照组。这些数据表明，ESR1 OE卵巢对MXC及其代谢物引起的闭锁更敏感。体外和。在体内与对照相比。

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