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Cellular signaling perturbation by natural products

机译：天然产物对细胞信号的干扰

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Cancer cells are known to have alterations in multiple cellular signaling pathways and because of the complexities in the communication between multiple signaling networks, the treatment and the cure for most human malignancies is still an open question. Perhaps, this is the reason why specific inhibitors that target only one pathway have been typically failed in cancer treatment. However, the in vitro and in vivo studies have demonstrated that some natural products such as isoflavones, indole-3-carbinol (13C), 3,3'-diindolylmethane (DIM), curcumin, (-)-epigallocatechin-3-gallate (EGCG), resveratrol, lycopene, etc, have inhibitory effects on human and animal cancers through targeting multiple cellular signaling pathways and thus these "natural agents" could be classified as multi-targeted agents. This is also consistent with the epidemiological studies showing that the consumption of fruits, soybean and vegetables is associated with reduced risk of several types of cancers. By regulating multiple important cellular signaling pathways including NF-kappa B, Akt, MAPK, Wnt, Notch, p53, AR, ER, etc, these natural products are known to activate cell death signals and induce apoptosis in pre-cancerous or cancer cells without affecting normal cells. Therefore, non-toxic "natural agents" harvested from the bounties of nature could be useful either alone or in combination with conventional therapeutics for the prevention of tumor progression and/or treatment of human malignancies.
机译：已知癌细胞在多个细胞信号通路中具有改变，并且由于多个信号网络之间的通信复杂，因此对于大多数人类恶性肿瘤的治疗和治愈仍然是一个悬而未决的问题。也许，这就是为什么仅靶向一种途径的特异性抑制剂在癌症治疗中通常失败的原因。但是，体外和体内研究表明，某些天然产物，如异黄酮，吲哚-3-甲醇（13C），3,3'-二吲哚甲烷（DIM），姜黄素，（-）-表没食子儿茶素-3-没食子酸酯（ EGCG，白藜芦醇，番茄红素等通过靶向多种细胞信号传导途径对人和动物癌症具有抑制作用，因此这些“天然药物”可以归类为多靶向药物。这也与流行病学研究一致，流行病学研究表明食用水果，大豆和蔬菜与降低几种癌症的风险有关。通过调节多种重要的细胞信号传导途径，包括NF-κB，Akt，MAPK，Wnt，Notch，p53，AR，ER等，已知这些天然产物可激活细胞死亡信号并诱导癌前或癌细胞中的细胞凋亡。影响正常细胞。因此，从大自然的恩赐中收获的无毒“天然药物”可以单独使用或与常规疗法组合用于预防肿瘤进展和/或治疗人类恶性肿瘤。

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