Molecular basis of lysophosphatidic acid-induced NF-κB activation

Sun W.; Yang J.

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Molecular basis of lysophosphatidic acid-induced NF-κB activation

机译：溶血磷脂酸诱导的NF-κB活化的分子基础

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PKC, β-arrestin 2, CARMA3, BCL10, MALT1, TRAF6 and MEKK3 are signaling proteins that have a key role in G protein-coupled receptor (GPCR)-mediated activation of nuclear factor-κB (NF-κB) pathway in nonhematopoietic cells in response to lysophosphatidic acid (LPA) stimulation. The PKC, β-arrestin 2, CARMA3-BCL10-MALT1-TRAF6 signalosome, and MEKK3 functions as a link between GPCR signaling and IKK-NF-κB activation. Here we briefly summarize recent progress in the understanding of the molecular and biological functions of these proteins in GPCR-mediated NF-κB activation in nonhematopoietic cells.

机译：PKC，β-arrestin2，CARMA3，BCL10，MALT1，TRAF6和MEKK3是信号蛋白，在非造血细胞中由G蛋白偶联受体（GPCR）介导的核因子-κB（NF-κB）途径活化中起关键作用响应溶血磷脂酸（LPA）刺激。 PKC，β-arrestin2，CARMA3-BCL10-MALT1-TRAF6信号小体和MEKK3充当GPCR信号传导与IKK-NF-κB激活之间的链接。在这里，我们简要概述了在非造血细胞中GPCR介导的NF-κB激活中这些蛋白质的分子和生物学功能的理解方面的最新进展。

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《Cellular Signalling》 |2010年第12期|共5页
作者
Sun W.; Yang J.;
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正文语种 eng
中图分类细胞形态学;
关键词
GPCR; LPA; NF-κB;

机译：GPCR;LPA;NF-κB;

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专利

1. Molecular basis of lysophosphatidic acid-induced NF-κB activation [J] . Sun W., Yang J. Cellular Signalling . 2010,第12期

机译：溶血磷脂酸诱导的NF-κB活化的分子基础
2. Protein kinase C|[alpha]|-CARMA3 signaling axis links Ras to NF-|[kappa]|B for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells [J] . C Mahanivong, H M Chen, S W Yee, Oncogene . 2008,第9期

机译：蛋白激酶C |α-α| -carmA3信号轴线与溶血磷脂酸诱导的卵巢癌细胞中尿激酶纤溶酶原激活剂表达的RA至NF- | B
3. Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-κB activation and interleukin-8 secretion in human bronchial epithelial cells [J] . Andrew MORRIS, Bahman SAATIAN, David?N. BRINDLEY, The biochemical journal . 2005,第2期

机译：脂质磷酸磷酸酶-1调节人支气管上皮细胞中溶血磷脂酸诱导的钙释放，NF-κB激活和白介素8分泌
4. Toll-like receptor 2-mediated NF-κB activation by damage-associated molecular patterns on biomaterial surfaces [C] . Lindsay E. Fitzpatrick, Laura A. McKiel Society for Biomaterials annual meeting and exposition . 2017

机译：Toll样受体2介导的生物材料表面的损伤相关分子模式激活NF-κB
5. The role of beta-arrestin 2 in lysophosphatidic acid-induced NF-kappaB activation. [D] . Sun, Jiyuan. 2009

机译：β-arrestin2在溶血磷脂酸诱导的NF-κB活化中的作用。
6. Molecular Basis of Lysophosphatidic Acid-Induced NF-κB Activation [O] . Wenjing Sun, Jianhua Yang -1

机译：溶血磷脂酸诱导的NF-κB活化的分子基础
7. The LUBAC participates in lysophosphatidic acid-induced NF-κB activation [O] . Tiphaine Douanne, Sarah Chapelier, Robert Rottapel, 2020

机译：润滑油参与溶血磷脂酸诱导的NF-κB活化

Molecular basis of lysophosphatidic acid-induced NF-κB activation

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