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BRI2 and BRI3 are functionally distinct phosphoproteins

机译:BRI2和BRI3是功能不同的磷蛋白

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摘要

Three BRI protein family members have been identified. Among these are BRI3 and BRI2, the latter is associated with Familial Danish and Familial British dementias. 'In silico' sequence analysis identified putative PP1 binding sites in BRI2 and BRI3. This is singularly important, given that protein phosphorylation is a major mechanism regulating intracellular processes. Protein phosphatase 1 (PP1) interacting proteins (PIPs) are fundamental in determining substrate specificity and subcellular localization of this phosphatase. More than 200 PIPs have thus far been reported.
机译:已经确定了三个BRI蛋白家族成员。其中包括BRI3和BRI2,后者与丹麦家族性家族性痴呆和英国家族性痴呆有关。 “计算机模拟”序列分析确定了BRI2和BRI3中假定的PP1结合位点。鉴于蛋白质磷酸化是调节细胞内过程的主要机制,因此这非常重要。蛋白质磷酸酶1(PP1)相互作用蛋白(PIP)在确定该磷酸酶的底物特异性和亚细胞定位中至关重要。迄今为止,已经报告了200多个PIP。

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