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首页> 外文期刊>Cereal Chemistry >Physicochemical and pharmaceutical properties of carboxymethyl rice starches modified from native starches with different amylose content.
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Physicochemical and pharmaceutical properties of carboxymethyl rice starches modified from native starches with different amylose content.

机译：从具有不同直链淀粉含量的天然淀粉改性的羧甲基大米淀粉的理化和药学特性。

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Carboxymethyl rice starches (CMRS) were prepared from nine strains of native rice starches with amylose contents of 14.7-29.1%. The reaction was conducted at 50 degrees C for 120 min using monochloroacetic acid as a reagent under alkaline conditions and 1-propanol as a solvent. After determining the degree of substitution (DS), the physicochemical properties including water solubility, pH, and viscosity of 1% (w/v) solution, scanning electron microscopy (SEM), and X-ray diffraction (XRD) analyses of the granules, as well as some pharmaceutical properties of CMRS powders and pastes were investigated. The DS range was 0.25-0.40. All CMRS dissolved in unheated water and formed viscous gel. A good positive correlation was observed between amylose content and DS (r=0.9278) but not viscosity. SEM and XRD concurrently revealed significant physical alteration of CMRS granules compared with those of native starches, which reflected the changes in the properties of CMRS. At 3% (w/w), CMRS can function as tablet binder in the wet granulation of both water-soluble and water-insoluble diluents. The tablets compressed from these granules showed good hardness with fewer capping problems compared with those prepared using the pregelatinized native rice starch as a binder. In addition, most CMRS pastes formed clear films with varying film characteristics, depending upon the amylose content of the native starches. This type of modified rice starch can potentially be employed as a tablet binder and film-former for pharmaceutical dosage formulations.
机译：从9个直链淀粉含量为14.7-29.1％的天然大米淀粉菌株制备羧甲基大米淀粉（CMRS）。使用一氯乙酸作为试剂，在碱性条件下，以1-丙醇作为溶剂，在50℃下反应120分钟。确定取代度（DS）后，对颗粒进行理化性质分析，包括水溶性，pH和1％（w / v）溶液的粘度，扫描电子显微镜（SEM）和X射线衍射（XRD）分析研究了CMRS粉末和糊剂的一些药物特性。 DS范围是0.25-0.40。所有CMRS均溶于未加热的水中，形成粘稠的凝胶。在直链淀粉含量和DS之间观察到良好的正相关性（r = 0.9278），但没有粘度。 SEM和XRD同时显示出与天然淀粉相比，CMRS颗粒发生了明显的物理变化，这反映了CMRS特性的变化。在3％（w / w）的浓度下，CMRS可以在水溶性和非水溶性稀释剂的湿法制粒中用作片剂粘合剂。与使用预胶化的天然大米淀粉作为粘合剂制得的片剂相比，由这些颗粒压制的片剂显示出良好的硬度，并且具有较少的压盖问题。另外，取决于天然淀粉的直链淀粉含量，大多数CMRS糊剂形成具有不同膜特性的透明膜。这种类型的改性大米淀粉可以潜在地用作药物剂型的片剂粘合剂和成膜剂。

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