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ErbB2 and ErbB3 do not quantitatively modulate ligand-induced ErbB4 tyrosine phosphorylation

机译：ErbB2和ErbB3不能定量调节配体诱导的ErbB4酪氨酸磷酸化

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The ErbB family of receptor tyrosine kinases consists of four members: the epidermal growth factor receptor (EGFR/ErbB1), ErbB2/HER2/Neu, ErbB3/HER3, and ErbB4/HER4. ErbB2 is an "orphan" for which there is no naturally occurring, soluble ligand. ErbB3 lacks tyrosine kinase activity. Thus, we hypothesized that ErbB2 enhances ligand-induced ErbB family receptor signalling through mass action. In contrast, we hypothesized that ErbB3 reduces ligand-induced ErbB family receptor signalling by forming receptor heterodimers that cannot undergo bidirectional cross-phosphorylation; We tested these hypotheses using three cell lines that express equal levels of ErbB4. One expresses ErbB4 alone, the second expresses ErbB2 and ErbB4, and the third expresses Erb133 and ErbB4. We treated the cells with the ErbB4 ligands betacellulin (BTC) and neuregulin 1 beta (NRG1beta) and assayed ErbB4 tyrosine phosphorylation. ErbB2 and Erb133 do not affect the amount of ligand-induced ErbB4 tyrosine phosphorylation. We will discuss these findings within the context of a model for ErbB receptor signalling. (C) 2002 Elsevier Science Inc. All rights reserved. [References: 23]
机译：ErbB受体酪氨酸激酶家族由四个成员组成：表皮生长因子受体（EGFR / ErbB1），ErbB2 / HER2 / Neu，ErbB3 / HER3和ErbB4 / HER4。 ErbB2是一个“孤儿”，没有天然存在的可溶配体。 ErbB3缺乏酪氨酸激酶活性。因此，我们假设ErbB2通过质量作用增强配体诱导的ErbB家族受体信号传导。相反，我们假设ErbB3通过形成不能进行双向交叉磷酸化的受体异二聚体来减少配体诱导的ErbB家族受体信号传导。我们使用表达相等水平的ErbB4的三种细胞系测试了这些假设。一种表示单独的ErbB4，第二种表示ErbB2和ErbB4，第三种表示Erb133和ErbB4。我们用ErbB4配体βcellulin（BTC）和neuregulin 1 beta（NRG1beta）处理细胞，并检测了ErbB4酪氨酸磷酸化。 ErbB2和Erb133不会影响配体诱导的ErbB4酪氨酸磷酸化的量。我们将在ErbB受体信号传导模型的背景下讨论这些发现。 （C）2002 Elsevier Science Inc.保留所有权利。 [参考：23]

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