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首页> 外文期刊>Cellular & molecular biology letters. >In silico SCREENING OF ALLEGED miRNAs ASSOCIATED WITH CELL COMPETITION: AN EMERGING CELLULAR EVENT IN CANCER
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In silico SCREENING OF ALLEGED miRNAs ASSOCIATED WITH CELL COMPETITION: AN EMERGING CELLULAR EVENT IN CANCER

机译：与细胞竞争相关的miRNA的计算机筛选：癌症中的新兴细胞事件

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摘要

Cell competition is identified as a crucial phenomenon for cancer and organ development. There is a possibility that microRNAs (miRNAs) may play an important role in the regulation of expression of genes involved in cell competition. In silico screening of miRNAs is an effort to abridge, economize and expedite the experimental approaches to identification of potential miRNAs involved in cell competition, as no study has reported involvement of miRNAs in cell competition to date. In this study, we used multiple screening steps as follows: (i) selection of cell competition related genes of Drosophila through a literature survey; (ii) homology study of selected cell competition related genes; (iii) identification of miRNAs that target conserved cell competition-related genes through prediction tools; (iv) sequence conservation analysis of identified miRNAs with human genome; (v) identification of conserved cell competition miRNAs using their expression profiles and exploration of roles of their homologous human miRNAs. This study led to the identification of nine potential cell competition miRNAs in the Drosophila genome. Importantly, eighteen human homologs of these nine potential Drosophila miRNAs are well reported for their involvement in different types of cancers. This confirms their probable involvement in cell competition as well, because cell competition is well justified for its involvement in cancer initiation and maintenance.
机译：细胞竞争被认为是癌症和器官发育的关键现象。 microRNA（miRNA）有可能在调控细胞竞争基因的表达中起重要作用。对miRNA进行计算机筛选是为了简化，节约和加快实验方法，以鉴定参与细胞竞争的潜在miRNA，因为迄今为止尚无研究报道miRNA参与细胞竞争。在这项研究中，我们采用了以下多个筛选步骤：（i）通过文献调查选择果蝇的细胞竞争相关基因; （ii）所选细胞竞争相关基因的同源性研究; （iii）通过预测工具鉴定靶向保守细胞竞争相关基因的miRNA; （iv）鉴定具有人类基因组的miRNA的序列保守性分析; （v）使用其表达谱鉴定保守的细胞竞争miRNA，并探索其同源人miRNA的作用。这项研究导致在果蝇基因组中鉴定出九种潜在的细胞竞争性miRNA。重要的是，据报道，这九种潜在果蝇miRNA的十八种人类同源物参与了不同类型的癌症。这也证实了它们也可能参与了细胞竞争，因为细胞竞争因其参与癌症的发生和维持而被证明是合理的。

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