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首页> 外文期刊>Cell transplantation >Plasma as a scaffold for regeneration of neural precursor cells after transplantation into rats with spinal cord injury.
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Plasma as a scaffold for regeneration of neural precursor cells after transplantation into rats with spinal cord injury.

机译：血浆作为移植到脊髓损伤大鼠后神经前体细胞再生的支架。

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摘要

The present study investigated whether plasma could be useful as a scaffold for cell transplantation in rats with spinal cord injury (SCI). Transplantation of cells with plasma promoted the recovery of SCI-induced motor dysfunction. Immunohistochemical analysis revealed that the grafted cells had differentiated into the neural lineage. When dissociated neural precursor cells were cultured with plasma, extensive neurite outgrowth was observed along with increased expression of p35 and NF68. Neural markers were also expressed by the cultured cells. Culture with plasma reduced thymidine incorporation, but promoted cell growth and increased the RNA contents. These findings suggest that the cells underwent differentiation into neurons in the presence of plasma. In conclusion, plasma could be a promising scaffold for cell transplantation therapy.
机译：本研究调查了血浆是否可以用作脊髓损伤（SCI）大鼠细胞移植的支架。血浆细胞移植促进了SCI诱导的运动功能障碍的恢复。免疫组织化学分析表明，移植细胞已分化为神经谱系。当解离的神经前体细胞与血浆一起培养时，观察到广泛的神经突向外生长以及p35和NF68的表达增加。神经标志物也由培养的细胞表达。用血浆培养可减少胸苷的掺入，但可促进细胞生长并增加RNA含量。这些发现表明在血浆存在下，细胞经历了分化为神经元的过程。总之，血浆可能是用于细胞移植治疗的有希望的支架。

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