beta-Hydroxybutyrate: A signaling metabolite in starvation response?

Rojas-Morales Pedro; Tapia Edilia; Pedraza-Chaverri Jose

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beta-Hydroxybutyrate: A signaling metabolite in starvation response?

机译：β-羟基丁酸酯：饥饿反应中的信号代谢物？

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Ketone bodies beta-hydroxybutyrate (BHB) and acetoacetate are important metabolic substrates for energy production during prolonged fasting. However, BHB also has signaling functions. Through several metabolic pathways or processes, BHB modulates nutrient utilization and energy expenditure. These findings suggest that BHB is not solely a metabolic intermediate, but also acts as a signal to regulate metabolism and maintain energy homeostasis during nutrient deprivation. We briefly summarize the metabolism and emerging physiological functions of ketone bodies and highlight the potential role for BHB as a signaling molecule in starvation response. (C) 2016 Elsevier Inc. All rights reserved.

机译：酮体β-羟基丁酸酯（BHB）和乙酰乙酸酯是长期禁食期间能量产生的重要代谢底物。但是，BHB也具有信令功能。通过多种代谢途径或过程，BHB调节营养物质利用和能量消耗。这些发现表明，BHB不仅是代谢的中间产物，而且还作为营养缺乏时调节新陈代谢和维持能量稳态的信号。我们简要概述了酮体的代谢和新兴的生理功能，并强调了BHB作为饥饿反应中的信号分子的潜在作用。（C）2016 Elsevier Inc.保留所有权利。

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《Cellular Signalling》 |2016年第8期|共7页
作者
Rojas-Morales Pedro; Tapia Edilia; Pedraza-Chaverri Jose;
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正文语种 eng
中图分类细胞形态学;
关键词
beta-Hydroxybutyrate; Signaling; Starvation; Energy expenditure; Autophagy;

机译：β-羟基丁酸酯;信号传导;饥饿;能量消耗;自噬;

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beta-Hydroxybutyrate: A signaling metabolite in starvation response?

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