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Circulating nucleic acids as a new diagnostic tool.

机译:循环核酸是一种新的诊断工具。

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摘要

The discovery of circulating nucleic acids in the 1940s opened up new possibilities for the non-invasive detection, monitoring and screening of various human disorders. Several tumour markers that enable early cancer detection or tumour behaviour prediction have been detected in the plasma of cancer patients. Maternal plasma analysis can be used to detect certain fetal abnormalities, with the quantification of cell-free nucleic acids used to screen for several pregnancy-associated disorders. Some other applications are in transplant monitoring and graft rejection assessment, and in certain medical emergencies such as trauma and burn severity stratification. Many studies have yielded promising results in this field, but the techniques have yet to be applied in routine clinical practice. Large-scale studies using similar technologies and a broad spectrum of patients are still needed to verify the results of the various studies.
机译:1940年代发现循环核酸,为无创检测,监测和筛选各种人类疾病开辟了新的可能性。在癌症患者的血浆中已经检测到几种能够早期检测癌症或预测肿瘤行为的肿瘤标志物。母体血浆分析可用于检测某些胎儿异常,并定量用于筛选多种妊娠相关疾病的无细胞核酸。其他一些应用还用于移植物监测和移植物排斥评估,以及某些医学紧急情况,例如创伤和烧伤严重程度分层。在该领域,许多研究已经产生了可喜的结果,但是该技术尚未在常规临床实践中应用。为了验证各种研究的结果,仍需要使用类似技术和广泛患者的大规模研究。

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