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P130Cas: A key signalling node in health and disease

机译：P130Cas：健康和疾病的关键信号转导点

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摘要

p130Cas/breast cancer anti-oestrogen resistance 1 (BCAR1) is a member of the Cas (Crk-associated substrate) family of adaptor proteins, which have emerged as key signalling nodes capable of interactions with multiple proteins, with important regulatory roles in normal and pathological cell function. The Cas family of proteins is characterised by the presence of multiple conserved motifs for protein-protein interactions, and by extensive tyrosine and serine phosphorylations. Recent studies show that p130Cas contributes to migration, cell cycle control and apoptosis. p130Cas is essential during early embryogenesis, with a critical role in cardiovascular development. Furthermore, p130Cas has been reported to be involved in the development and progression of several human cancers. p130Cas is able to perform roles in multiple processes due to its capacity to regulate a diverse array of signalling pathways, transducing signals from growth factor receptor tyrosine kinases, non-receptor tyrosine kinases, and integrins. In this review we summarise the current understanding of the structure, function, and regulation of p130Cas, and discuss the importance of p130Cas in both physiological and pathophysiological settings, with a focus on the cardiovascular system and cancer.
机译：p130Cas /乳腺癌抗雌激素抗性1（BCAR1）是Cas（Crk相关底物）衔接蛋白家族的成员，该衔接蛋白已成为能够与多种蛋白相互作用的关键信号节点，在正常和正常情况下具有重要的调节作用。病理细胞功能。 Cas家族的蛋白质的特征是存在多个蛋白质-蛋白质相互作用的保守基序，以及广泛的酪氨酸和丝氨酸磷酸化。最近的研究表明，p130Cas有助于迁移，细胞周期控制和细胞凋亡。 p130Cas在早期胚胎发生过程中至关重要，在心血管发育中起关键作用。此外，据报道，p130Cas与几种人类癌症的发生和发展有关。 p130Cas能够调节多种信号通路，转导来自生长因子受体酪氨酸激酶，非受体酪氨酸激酶和整联蛋白的信号，因此能够在多个过程中发挥作用。在这篇综述中，我们总结了对p130Cas的结构，功能和调控的当前理解，并讨论了p130Cas在生理和病理生理环境中的重要性，重点是心血管系统和癌症。

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