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Multiple Myeloma Precursor Disease: Current Clinical and Epidemiological Insights and Future Opportunities

机译：多发性骨髓瘤前体疾病：当前的临床和流行病学见解和未来的机会

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In this issue of ONCOLOGY, Dr. Robert Kyle and colleagues provide their clinical and epidemiological perspective on monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM)-a perspective that is based on more than three decades of experience. Benign monoclonal protein was first described by Walden-strom in 1960 after abnormal narrow hypergammaglobu-linemia bands were noted in the serum of healthy individuals on serum protein electrophoresis.[1] In 1978, Kyle coined the term "monoclonal gammopathy of undetermined significance (MGUS)" after observing that asymptomatic patients with monoclonal protein have a higher risk of developing multiple myeloma, Waldenstrom macroglobulinemia, light-chain amy-loidosis, and related disorders. [2] Since then, definitions of MGUS have undergone several revisions. Today, three distinct clinical subtypes of MGUS (non-IgM MGUS, IgM MGUS, and light-chain MGUS) have been delineated. [3,4] The review by Kyle et al discusses these subtypes and their epidemiological relationships with corresponding malignancies. In addition, the paper sheds light on recent discoveries regarding etiologic risk factors, complications, and clinical predictors of transformation from a precursor state to full-blown malignancy.
机译：在本期《肿瘤学》中，Robert Kyle博士及其同事提供了具有不确定性的单发性丙种球蛋白病（MGUS）和阴燃性骨髓瘤（SMM）的临床和流行病学观点，该观点基于三十多年的经验。良性单克隆蛋白最早是由Walden-strom在1960年通过血清蛋白电泳在健康个体的血清中发现异常狭窄的高伽玛球蛋白-贫血条带后提出的[1]。 1978年，Kyle观察到无症状的单克隆蛋白患者罹患多发性骨髓瘤，Waldenstrom巨球蛋白血症，轻链淀粉样变性和相关疾病的风险较高，因此创造了“意义不明的单克隆丙种球蛋白病（MGUS）”一词。 [2]从那时起，MGUS的定义经历了几次修订。如今，已经划定了MGUS的三种不同的临床亚型（非IgM MGUS，IgM MGUS和轻链MGUS）。 [3,4] Kyle等人的综述讨论了这些亚型及其与相应恶性肿瘤的流行病学关系。此外，本文揭示了病因危险因素，并发症和从前兆状态向成熟恶性肿瘤转变的临床预测因素的最新发现。

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