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首页> 外文期刊>Oncology reports >Klotho inhibits the capacity of cell migration and invasion in cervical cancer
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Klotho inhibits the capacity of cell migration and invasion in cervical cancer

机译：Klotho抑制宫颈癌中细胞迁移和侵袭的能力

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摘要

Aberrant activation of the Wnt/β-catenin signaling pathway is common in human cervical cancers. However, the mechanisms of Wnt activation in cervical cancer remain largely unknown. In the present study, we demonstrate that Klotho, a Wnt antagonist, is downregulated in invasive human cervical tumors and in a cell line we analyzed. Our data demonstrated that in vivo Klotho expression was not observed in invasive cervical carcinoma. In vitro restoration of Klotho expression in SiHa cells resulted in a decreased cell motility and invasiveness through upregulation of E-cadherin, downregulation of N-cadherin and reduced expression of MMP7 and -9. Ectopic expression of Klotho also reduced the expression of the epithelial-to-mesenchymal transition (EMT) transcription factors Slug and Twist. Furthermore, Klotho causes a significant inhibition of the Wnt/β-catenin pathway in cervical cancer cells, as supported by the expression of Wnt/β-catenin transcriptional target genes such as c-Myc and cyclin D1. Consequently, our findings demonstrate for the first time that Klotho regulates tumor invasion through the EMT process and provide novel mechanistic insights into the role of Klotho in cervical cancer progression and contribute to treatment for metastatic cervical cancer patients.
机译：Wnt /β-catenin信号通路的异常激活在人类宫颈癌中很常见。然而，在宫颈癌中Wnt激活的机制仍是未知的。在本研究中，我们证明了Wnt拮抗剂Klotho在人类宫颈浸润性肿瘤和我们分析的细胞系中下调。我们的数据表明，在浸润性宫颈癌中未观察到体内Klotho表达。 SiHa细胞中Klotho表达的体外恢复导致E-cadherin上调，N-cadherin下调以及MMP7和-9表达降低导致细胞运动性和侵袭性降低。 Klotho的异位表达还减少了上皮到间质转化（EMT）转录因子Slug和Twist的表达。此外，Klotho引起宫颈癌细胞中Wnt /β-catenin途径的显着抑制，这由Wnt /β-catenin转录靶基因（例如c-Myc和cyclin D1）的表达所支持。因此，我们的发现首次证明了Klotho通过EMT过程调节肿瘤的侵袭，并为Klotho在子宫颈癌进展中的作用提供了新颖的力学见解，并为转移性子宫颈癌患者的治疗做出了贡献。

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