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首页> 外文期刊>Oncology research and treatment. >Whole Brain Radiotherapy-Based Combined Modality Treatment of Brain Metastases from Non-Small Cell Lung Cancer: A Retrospective Analysis of Prognostic Factors
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Whole Brain Radiotherapy-Based Combined Modality Treatment of Brain Metastases from Non-Small Cell Lung Cancer: A Retrospective Analysis of Prognostic Factors

机译：基于全脑放疗的非小细胞肺癌脑转移联合治疗方法：预后因素回顾性分析

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Background: The prognostic factors for patients with brain metastases from non-small cell lung cancer treated with whole brain radiotherapy (WBRT)-based combined modality therapy were investigated. Materials and Methods: Out of 135 patients treated with WBRT, 47 (34.8%) received a radiation boost, 84 (62.2%) underwent systemic chemotherapy, and 39 (28.9%) were given epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). Results: The mean survival time was 9.3 months, and the 1-year and 2-year survival rates were 46.3 and 16.1%, respectively. In univariate analysis, improved survival was associated with age <60 years, no extracranial metastasis, Karnofsky performance score >= 70, >= 3 cycles of chemotherapy after diagnosis of brain metastases, combined treatment with EGFR-TKIs, and no metastases in the cerebellum. In multivariate analysis, the above prognostic factors maintained significance with the exception of age. In an additional analysis of the 58 patients with 1-3 brain metastases, combination of WBRT with radiation boost was associated with better survival. Conclusion: We confirm previously described prognostic factors. Moreover, we found the absence of cerebellar metastases to be an independent prognostic factor for favorable outcome.
机译：背景：研究了基于全脑放疗（WBRT）的联合模式治疗非小细胞肺癌脑转移患者的预后因素。材料和方法：在WBRT治疗的135例患者中，有47例（34.8％）接受了放疗，84例（62.2％）进行了全身化学疗法，并且39例（28.9％）接受了表皮生长因子受体酪氨酸激酶抑制剂（EGFR-TKIs） ）。结果：平均生存时间为9.3个月，1年和2年生存率分别为46.3和16.1％。在单因素分析中，生存改善与年龄<60岁，无颅外转移，卡诺夫斯基表现评分> = 70，诊断为脑转移后，≥EGFR-TKIs联合治疗以及小脑无转移的3个周期化疗相关。 。在多变量分析中，上述预后因素除年龄外均具有重要意义。在对58例具有1-3个脑转移的患者的进一步分析中，WBRT与放疗联合可提高生存率。结论：我们证实了先前描述的预后因素。此外，我们发现无小脑转移是预后良好的独立预后因素。

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