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首页> 外文期刊>Oncology research and treatment. >Glutathione S-Transferase T1 and M1 Polymorphisms Are Associated with Lung Cancer Risk in a Gender-Specific Manner
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Glutathione S-Transferase T1 and M1 Polymorphisms Are Associated with Lung Cancer Risk in a Gender-Specific Manner

机译：谷胱甘肽S-转移酶T1和M1多态性与性别风险相关的肺癌风险。

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Background: Glutathione S-transferase (GST) T1 and M1 are detoxification enzymes which neutralize various carcinogenic compounds. Polymorphisms of the GSTT1 and GSTM1 genes which encode the enzymes could be associated with cancer risk. Patients and Methods: We investigated the association of GSTT1 and GSTM1 null polymorphisms with lung cancer risk in a tightly matched, considerably large sample in China. Genotyp-ing was performed utilizing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and DNA sequencing, and associations were measured by using logistic regression analysis. Results: We found that the null genotypes of both polymorphisms resulted in an increased lung cancer risk, with an odds ratio (OR) of 1.57 (95% confidence interval (CD 1.23-2.00) for GSTT1 and OR 1.87 (95% Cl 1.46-2.39) for GSTM1 (p < 0.01). Significant associations remained after stratification by histopathology (p < 0.01) and smoking status (p < 0.05). When gender-stratified association was performed, we found that the GSTT1 null genotype resulted in an increased risk among males (adjusted OR 2.95, 95% Cl 2.07-4.20; p < 0.01) but not females (p > 0.05), while the GSTM1 null genotype resulted in an increased risk among females (adjusted OR 2.18, 95% Cl 1.54-3.10; p < 0.01) but not males (p < 0.05). Conclusion: Polymorphisms in GSTT1 and GSTM1 are associated with the risk of lung cancer in a gender-specific manner.
机译：背景：谷胱甘肽S-转移酶（GST）T1和M1是中和各种致癌化合物的解毒酶。编码该酶的GSTT1和GSTM1基因的多态性可能与癌症风险有关。患者和方法：我们在一个紧密匹配且相当大的中国样本中，研究了GSTT1和GSTM1无效多态性与肺癌风险的关系。利用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析和DNA测序进行基因分型，并通过逻辑回归分析测量关联。结果：我们发现两种多态性的无效基因型都会导致肺癌风险增加，GSTT1的比值比（OR）为1.57（95％置信区间（CD 1.23-2.00），OR为1.87（95％Cl 1.46-） 2.39）对于GSTM1（p <0.01）。通过组织病理学（p <0.01）和吸烟状态（p <0.05）进行分层后，仍然存在重要的关联。当进行性别分层关联时，我们发现GSTT1无效基因型导致了增加的关联。男性的风险（校正后的OR为2.95，95％Cl 2.07-4.20; p <0.01），但女性没有（P> 0.05），而GSTM1无效基因型导致女性的风险较高（校正的OR为2.18，95％Cl 1.54）。 3.10; p <0.01），但男性没有（p <0.05）结论：GSTT1和GSTM1中的多态性与性别相关的肺癌风险相关。

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