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首页> 外文期刊>Ophthalmic surgery, lasers & imaging: the official journal of the International Society for Imaging in the Eye >Intravitreal triamcinolone acetonide preceding photodynamic therapy for exudative age-related macular degeneration.
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Intravitreal triamcinolone acetonide preceding photodynamic therapy for exudative age-related macular degeneration.

机译：玻璃体腔注射曲安奈德在进行光动力治疗前用于与年龄相关的渗出性黄斑变性。

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摘要

BACKGROUND AND OBJECTIVE: To evaluate the efficacy of intravitreal triamcinolone acetonide 1 week before photodynamic therapy (PDT) with verteporfin in the treatment of exudative age-related macular degeneration (AMD). PATIENTS AND METHODS: Retrospective chart review of 70 eyes of 66 consecutive patients who were treated with intravitreal triamcinolone acetonide followed by standard PDT 1 week later. Group 1 consisted of 42 eyes that received one or more previous treatments with PDT alone and responded poorly. Group 2 consisted of 28 eyes that had never received PDT. RESULTS: No statistically significant change in mean visual acuity was seen during the follow-up period for either group. At 12 months, 90% of group 1 eyes and 80% of group 2 eyes lost less than 2 lines of Snellen visual acuity. A mean of 1.24 additional PDT sessions were required in group 1 eyes and 1.04 additional sessions in group 2 eyes during the follow-up period. CONCLUSION: In eyes with exudative AMD, intravitreal triamcinolone acetonide preceding PDT with verteporfin results in stabilization of visual acuity and a decreased need for re-treatments with PDT. This regimen may be superior to PDT monotherapy.
机译：背景与目的：评价玻璃体腔内曲安奈德在维托泊芬光动力治疗（PDT）前1周治疗渗出性年龄相关性黄斑变性（AMD）的疗效。患者与方法：回顾性图表回顾了66例连续接受玻璃体腔注射曲安奈德丙酮治疗，然后在1周后进行标准PDT治疗的患者的70只眼。第1组由42只眼睛组成，它们仅接受一种或多种以前的PDT治疗，反应较差。第2组由从未接受PDT的28只眼睛组成。结果：在随访期间，两组的平均视力均无统计学意义的变化。在第12个月时，第1组眼睛的90％和第2组眼睛的80％丧失了不到2眼的Snellen视力。在随访期间，第1组眼睛平均需要增加1.24次PDT，第2组眼睛需要增加1.04次。结论：在渗出性AMD眼中，玻璃体腔注射曲安奈德在PDT之前加维替泊芬可导致视力稳定，减少PDT再治疗的需要。该方案可能优于PDT单药治疗。

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