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首页> 外文期刊>Ophthalmology >Corneal collagen cross-linking for ectasia after LASIK and photorefractive keratectomy: Long-term results
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Corneal collagen cross-linking for ectasia after LASIK and photorefractive keratectomy: Long-term results

机译：LASIK和光折射性角膜切除术后角膜胶原交联用于扩张的研究：长期结果

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摘要

Purpose: To report the long-term results of corneal collagen cross-linking (CXL) in ectasia after LASIK and photorefractive keratectomy (PRK). Design: Retrospective, interventional cases series. Participants: Twenty-six eyes of 26 patients (18 male, 8 female) with postoperative ectasia after LASIK (23 eyes) and PRK (3 eyes) were included with a mean age of 35±9 years at the time of treatment and a mean follow-up of 25 months (range, 12-62 months). Methods: All consecutive patients treated with CXL for progressive ectasia after LASIK or PRK at the Institute for Refractive and Ophthalmic Surgery, Zurich, Switzerland between 2004 and 2010 were included. Main Outcome Measures: Corrected distance visual acuity (CDVA), maximum keratometry readings (Kmax), minimum radius of curvature (Rmin), and 6 corneal topography indices were assessed in this study. Results: Mean CDVA before CXL was 0.5 logarithm of the minimum angle of resolution (logMAR) units, which improved to a mean of 0.3 logMAR units (P0.001). Corrected distance visual acuity improved 1 line or more in 19 cases and remained unchanged in 7 patients. Mean Kmax after CXL of 50.9±4.9 diopters (D) was significantly lower (P0.001) than mean pre-CXL Kmax of 52.8±5 D. The Rmin after CXL was increased significantly (P = 0.006), whereas the index of surface variance (P = 0.03), the index of vertical asymmetry (P = 0.04), the keratoconus index (P = 0.03), and the central keratoconus index (P = 0.016) were reduced significantly. Conclusions: Ectasia after LASIK and PRK was arrested by CXL with stabilization or improvement of CDVA and Kmax after a mean follow-up of 25 months. There were improvements in 4 topography indices, suggesting a more regular corneal surface. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
机译：目的：报告LASIK和光折角性角膜切除术（PRK）后角膜扩张的角膜胶原交联（CXL）的长期结果。设计：回顾性，介入病例系列。参与者：26眼LASIK术后术后水肿的26眼（男18眼，女8眼）有26眼（23眼）和PRK（3眼），在治疗时平均年龄为35±9岁，平均随访25个月（范围12-62个月）。方法：纳入2004年至2010年间在瑞士苏黎世屈光和眼科手术研究所接受LASIK或PRK手术后进行CXL进行性扩张性扩张的所有连续患者。主要观察指标：本研究评估了矫正的远视力（CDVA），最大角膜曲率读数（Kmax），最小曲率半径（Rmin）和6个角膜地形指数。结果：CXL之前的平均CDVA为最小分辨角（logMAR）单位的0.5对数，提高到0.3 logMAR单位的平均值（P <0.001）。矫正远视力19例改善1行或更多，而7例保持不变。 CXL为50.9±4.9屈光度（D）后的平均Kmax显着低于（P <0.001）CXL之前为52.8±5 D的平均Kmax。CXL后的Rmin显着增加（P = 0.006），而表面指数方差（P = 0.03），垂直不对称指数（P = 0.04），圆锥角膜指数（P = 0.03）和中央圆锥角膜指数（P = 0.016）显着降低。结论：平均随访25个月后，CXL可使LASIK和PRK术后的蜕膜扩张被CXL逮捕，CDVA和Kmax稳定或改善。 4个地形指数有所改善，提示角膜表面更规则。财务披露：作者对本文讨论的任何材料均没有所有权或商业利益。

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