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Differences in rates of glaucoma among Asian Americans and other racial groups, and among various Asian ethnic groups.

机译:亚裔美国人和其他种族群体以及各个亚洲种族群体之间的青光眼发生率差异。

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PURPOSE: To determine the incidence and prevalence of different glaucoma types among Asian Americans and other races, and evaluate the hazard for glaucoma among different races and Asian ethnicities. DESIGN: Retrospective, longitudinal, cohort study. PARTICIPANTS: A group of 2,259,061 eye care recipients, aged >/= 40, who were enrolled in a US managed-care network in 2001-2007. METHODS: Incidence and prevalence rates of open-angle glaucoma (OAG), narrow-angle glaucoma (NAG), and normal-tension glaucoma (NTG) were calculated and stratified by race and Asian ethnicity. Cox regression was performed to assess the hazard of developing OAG, NAG, and NTG for Asian Americans and other races, and among different Asian ethnicities, with adjustment for potentially confounding variables. MAIN OUTCOME MEASURES: Multivariable adjusted hazard of OAG, NAG, and NTG among different races and Asian ethnicities. RESULTS: The OAG prevalence rate for Asian Americans, 6.52%, was similar to that of Latinos (6.40%) and higher than that of non-Hispanic whites (5.59%). The NAG and NTG prevalence rates were considerably higher among Asian Americans (3.01% and 0.73%, respectively) relative to other races. After adjustment for potential confounding factors, Asian Americans had a 51% increased hazard of OAG (adjusted hazard ratio [HR], 1.51 [95% confidence interval (CI), 1.42-1.60]), a 123% increased hazard of NAG (adjusted HR, 2.23; CI, 2.07-2.41), and a 159% increased hazard of NTG (adjusted HR, 2.59; CI, 2.22-3.02) compared with non-Hispanic whites. Vietnamese Americans (adjusted HR, 3.78; CI, 3.19-4.48), Pakistani Americans (adjusted HR, 2.45, CI 1.50-4.01), and Chinese Americans (adjusted HR, 2.31, CI 2.06-2.59) had considerably higher hazards of NAG, whereas Japanese Americans (adjusted HR, 4.37, CI 3.24-5.89) had a substantially higher hazard of NTG, compared with non-Asian Americans. CONCLUSIONS: Given the rapid rise in the number of Asian Americans in the US population, resources should be devoted to identifying and treating glaucoma in these patients. Eye-care providers should be aware of the increased risk for OAG, NAG, and NTG among Asian Americans relative to other races. Knowing Asian-American patients' ancestral country of origin may permit more precise estimation of their risks for OAG, NAG, and NTG. FINANCIAL DISCLOSURE(S): The authors have no proprietary or commercial interest in any materials discussed in this article.
机译:目的:确定亚裔美国人和其他种族中不同类型的青光眼的发生率和患病率,并评估不同种族和亚洲种族中对青光眼的危害。设计:回顾性,纵向,队列研究。参加者:年龄在40岁以上的2,259,061名眼保健接受者,他们于2001年至2007年加入了美国管理医疗网络。方法:根据种族和亚洲种族,对开角型青光眼(OAG),窄角型青光眼(NAG)和正常血压型青光眼(NTG)的发生率和患病率进行了计算和分层。进行了Cox回归,以评估针对亚裔美国人和其他种族以及不同亚裔种族之间发展OAG,NAG和NTG的危害,并针对可能造成混淆的变量进行了调整。主要观察指标:不同种族和亚洲种族之间OAG,NAG和NTG的多变量调整危害。结果:亚裔美国人的OAG患病率为6.52%,与拉丁美洲人(6.40%)相似,高于非西班牙裔白人(5.59%)。与其他种族相比,亚裔美国人中的NAG和NTG患病率要高得多(分别为3.01%和0.73%)。在对潜在的混杂因素进行调整之后,亚裔美国人的OAG危害增加了51%(调整后的危害比[HR]为1.51 [95%置信区间(CI)为1.42-1.60]),NAG危害增加了123%(经调整与非西班牙裔白人相比,HR为2.23; CI为2.07-2.41),NTG的危害增加了159%(调整后的HR为2.59; CI为2.22-3.02)。越南裔美国人(调整后的HR,3.78; CI,3.19-4.48),巴基斯坦裔美国人(调整后的HR,2.45,CI 1.50-4.01)和华裔美国人(调整后的HR,2.31,CI 2.06-2.59)具有更大的NAG危害,而日裔美国人(调整后的HR,4.37,CI为3.24-5.89)与非亚裔美国人相比,NTG的危害要高得多。结论:鉴于美国人口中亚裔美国人的数量迅速增加,应将资源用于识别和治疗这些患者的青光眼。眼保健人员应意识到,相对于其他种族,亚裔美国人中OAG,NAG和NTG的风险增加。了解亚裔患者的祖传祖国可能会更准确地估计他们患OAG,NAG和NTG的风险。财务披露:作者对本文讨论的任何材料均无所有权或商业利益。

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