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首页> 外文期刊>Cellular and molecular life sciences: CMLS >Electroneutral absorption of NaCl by the aldosterone?sensitive distal nephron: implication for normal electrolytes homeostasis and blood pressure regulation
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Electroneutral absorption of NaCl by the aldosterone?sensitive distal nephron: implication for normal electrolytes homeostasis and blood pressure regulation

机译：醛固酮敏感的远端肾单位对NaCl的电中性吸收：对正常电解质的体内平衡和血压调节具有影响

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摘要

Sodium absorption by the distal part of the nephron, i.e., the distal convoluted tubule, the connecting tubule, and the collecting duct, plays a major role in the control of homeostasis by the kidney. In this part of the nephron, sodium transport can either be electroneutral or electrogenic. The study of electrogenic Na+ absorption, which is mediated by the epithelial sodium channel (ENaC), has been the focus of considerable interest because of its implication in sodium, potassium, and acid–base homeostasis. However, recent studies have highlighted the crucial role played by electroneutral NaCl absorption in the regulation of the body content of sodium chloride, which in turn controls extracellular fluid volume and blood pressure. Here, we review the identification and characterization of the NaCl cotransporter (NCC), the molecule accounting for the main part of electroneutral NaCl absorption in the distal nephron, and its regulators. We also discuss recent work describing the identification of a novel “NCC-like” transport system mediated by pendrin and the sodiumdriven chloride/bicarbonate exchanger (NDCBE) in the β-intercalated cells of the collecting system.
机译：肾的远侧部分，即远曲形小管，连接小管和收集管的钠吸收，在肾脏控制体内稳态中起着重要作用。在肾单位的这一部分，钠的转运可以是电子中性的或电动的。上皮钠通道（ENaC）介导的电Na +吸收的研究由于其与钠，钾和酸碱稳态有关，因此引起了人们的极大关注。但是，最近的研究强调了电中性NaCl吸收在调节氯化钠体内含量中的关键作用，而氯化钠又控制着细胞外液的体积和血压。在这里，我们审查的NaCl共转运蛋白（NCC），远端肾单位中电子中性NaCl吸收的主要部分的分子及其调节剂的鉴定和表征。我们还将讨论最近的工作，这些工作描述了在收集系统的β插入细胞中，由Pendrin和钠驱动的氯/碳酸氢根交换剂（NDCBE）介导的新型“ NCC样”转运系统的鉴定。

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