Diagnostic cellular organization features extracted from autofluorescence images

Jonathan M. Levitt; Martin Hunter; Claudia Mujat; Margaret McLaughlin-Drubin; Karl Munger; Irene Georgakoudi

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Diagnostic cellular organization features extracted from autofluorescence images

机译：从自发荧光图像提取的诊断性细胞组织特征

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Depth-resolved NADH autofluorescence images are shown to differentiate between normal and precancerous engineered tissues. An inverse power law behavior of the power spectral density (PSD) of these images is observed, indicating a self-affine organization of mitochondrial NADH at length scales 1-10 (mu)m. Power exponents of the PSD functions vary significantly with tissue depth and precancerous state, giving insight into the morphological changes associated with precancerous lesions and providing substantial potential for noninvasive clinical diagnosis of squamous epithelial lesions and tumors.

机译：深度分辨的NADH自发荧光图像显示出可以区分正常和癌前工程组织。观察到这些图像的功率谱密度（PSD）的逆幂定律行为，表明线粒体NADH的自仿射组织的长度范围为1-10μm。 PSD功能的幂指数随组织深度和癌前状态的变化而显着变化，从而深入了解与癌前病变相关的形态变化，并为鳞状上皮病变和肿瘤的非侵入性临床诊断提供了巨大潜力。

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《Optics Letters》 |2007年第22期|共3页
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Jonathan M. Levitt; Martin Hunter; Claudia Mujat; Margaret McLaughlin-Drubin; Karl Munger; Irene Georgakoudi;
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正文语种 eng
中图分类光学;
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机译：从自发荧光图像提取的诊断性细胞组织特征
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Diagnostic cellular organization features extracted from autofluorescence images

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