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首页> 外文期刊>Ophthalmology >Baseline predictors of visual acuity and retinal thickness outcomes in patients with retinal vein occlusion: Standard Care Versus COrticosteroid for REtinal Vein Occlusion Study report 10.
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Baseline predictors of visual acuity and retinal thickness outcomes in patients with retinal vein occlusion: Standard Care Versus COrticosteroid for REtinal Vein Occlusion Study report 10.

机译：视网膜静脉阻塞患者视力和视网膜厚度结局的基线预测指标：视网膜静脉阻塞研究的标准护理与皮质类固醇比较研究报告10。

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OBJECTIVE: To investigate baseline factors associated with visual acuity and central retinal thickness outcomes in patients with macular edema secondary to retinal vein occlusion in the Standard Care versus COrticosteroid for REtinal Vein Occlusion (SCORE) Study. DESIGN: Two multicenter, randomized clinical trials: one evaluating participants with central retinal vein occlusion (CRVO) and one evaluating participants with branch retinal vein occlusion (BRVO). PARTICIPANTS: Participants with follow-up data of 1 year or more, including 238 with CRVO and 367 with BRVO. METHODS: Visual acuity was measured by the electronic Early Treatment Diabetic Retinopathy Study (E-ETDRS) method, and central retinal thickness was measured by optical coherence tomography (OCT). Regression analysis related these outcomes to 20 baseline measures. Multiple P values were adjusted to control the false discovery rate. MAIN OUTCOME MEASURES: Outcome measures of visual acuity letter score included absolute change from baseline, a gain of >/= 15 from baseline, and a loss of >/= 15 from baseline. Outcome measures of center point thickness included absolute change from baseline, a measurement of /= 500 mum. Outcomes were assessed at 1 and 2 years. RESULTS: For CRVO and BRVO, younger age was associated with improved visual acuity and central retinal thickness outcomes. For CRVO, triamcinolone treatment and less severe anatomic abnormalities of the retina (center point thickness and areas of retinal hemorrhage, thickening, and fluorescein leakage) were predictive of better visual acuity outcomes. For BRVO, no history of coronary artery disease was predictive of improved visual acuity outcomes. For center point thickness outcomes, shorter duration of macular edema was associated with improvement in both disease entities. For CRVO, higher baseline visual acuity letter score was predictive of favorable OCT outcomes. For BRVO, lower baseline visual acuity letter score, presence of dense macular hemorrhage, and no prior grid photocoagulation were predictive of favorable OCT outcomes. CONCLUSIONS: Several factors were predictive of better visual acuity outcomes and more favorable OCT outcomes, including younger age and shorter duration of macular edema, respectively. These factors may assist clinicians in predicting disease course for patients with CRVO and BRVO.
机译：目的：在标准护理与皮质类固醇视网膜静脉阻塞（SCORE）研究中，研究与视网膜静脉阻塞继发性视网膜黄斑水肿的黄斑水肿患者的视力和视网膜中央中央厚度结局相关的基线因素。设计：两项多中心随机临床试验：一项评估视网膜中央静脉阻塞（CRVO）的参与者和一名评估视网膜分支静脉阻塞（BRVO）的参与者。参与者：随访数据为1年或1年以上的参与者，包括CRVO的238位和BRVO的367位。方法：通过电子早期糖尿病性视网膜病变研究（E-ETDRS）方法测量视力，并通过光学相干断层扫描（OCT）测量视网膜中央厚度。回归分析将这些结果与20种基线指标相关联。调整多个P值以控制错误发现率。主要观察指标：视敏度评分的结果指标包括：相对于基线的绝对变化，相对于基线的增幅> / = 15和相对于基线的增幅> / = 15。中心点厚度的结果度量值包括相对于基线的绝对变化，度量值 / = 500微米。在1年和2年评估结果。结果：对于CRVO和BRVO，年龄越小与视力提高和视网膜中央厚度预后相关。对于CRVO，曲安奈德治疗和不太严重的视网膜解剖异常（中心点厚度和视网膜出血面积，增厚和荧光素渗漏区域）可预示更好的视力结果。对于BRVO，没有冠状动脉疾病的病史可预示视力改善。对于中心点厚度结局，黄斑水肿持续时间的缩短与两种疾病实体的改善有关。对于CRVO，较高的基线视力字母得分可预示OCT结局良好。对于BRVO，较低的基线视力字母评分，密集的黄斑出血的存在以及既往的栅格光凝术均不能预示OCT的良好结果。结论：几个因素可预测更好的视力结果和更有利的OCT结果，分别包括年龄较小和黄斑水肿持续时间较短。这些因素可以帮助临床医生预测CRVO和BRVO患者的病程。

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