Biosensing based on two-photon fluorescence measurements through optical fibers

Jing Yong Ye; Mon Thiri Myaing; Theodore B. Norris; Thommey Thomas; James Baker

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Biosensing based on two-photon fluorescence measurements through optical fibers

机译：基于通过光纤的双光子荧光测量的生物传感

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We have performed two-photon fluorescence detection in a new scheme in which femtosecond laser pulses were delivered thorugh an optical fiber for nonlinear excitation and the emitted fluorescence was collected through the same fiber. Single-mode fibers were determined to give higher detection efficiency than multimode fibers, consistent with theoretical considerations. The utility of fiber-optic sensing based on two-photon fluorescence detection was proved by an experiment that measured the uptake of a targeted drug delivery agent into cultured cancer cells.

机译：我们已经在一种新的方案中执行了双光子荧光检测，其中飞秒激光脉冲通过光纤传输以进行非线性激发，并通过同一根光纤收集发射的荧光。确定的单模光纤比多模光纤具有更高的检测效率，这与理论上的考虑是一致的。通过测量目标药物递送剂对培养癌细胞的摄取的实验，证明了基于双光子荧光检测的光纤传感的实用性。

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《Optics Letters》 |2002年第16期|共3页
作者
Jing Yong Ye; Mon Thiri Myaing; Theodore B. Norris; Thommey Thomas; James Baker;
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中图分类光学;
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1. Biosensing based on two-photon fluorescence measurements through optical fibers [J] . Jing Yong Ye, Mon Thiri Myaing, Theodore B. Norris, Optics Letters . 2002,第16期

机译：基于通过光纤的双光子荧光测量的生物传感
2. Probing the erbium ion distribution in silica optical fibers with fluorescence based measurements [J] . Sidiroglou F., Roberts A., Baxter G.W. Journal of Non-Crystalline Solids: A Journal Devoted to Oxide, Halide, Chalcogenide and Metallic Glasses, Amorphous Semiconductors, Non-Crystalline Films, Glass-Ceramics and Glassy Composites . 2011,第22a23期

机译：使用基于荧光的测量来探测二氧化硅光纤中的ion离子分布
3. Precision Frequency Measurement of 87Rb 5S1/2 (F =2)→5D5/2 (F"=4) Two-Photon Transition through a Fiber-Based Optical Frequency Comb [J] . Wei Xia, Shao-Yang Dai, Yin Zhang, 中国物理快报：英文版 . 2016,第005期

机译：通过基于光纤的光频率梳精确测量87Rb 5S1 / 2（F = 2）→5D5 / 2（F“ = 4）双光子
4. Fluorescence optical-fiber measurement system for identification of oil type based on 3-D fluorescence spectrum parameterization [C] . Liping Shang, Ying Wang, Jinshan Shi Conference on Advanced Sensor Systems and Applications, Oct 15-18, 2002, Shanghai, China . 2002

机译：基于3-D荧光光谱参数化的用于识别油型的荧光光纤测量系统
5. Conventional and photonic crystal fiber based two-photon fluorescence biosensing. [D] . Myaing, Mon Thiri. 2004

机译：常规和基于光子晶体纤维的双光子荧光生物传感。
6. A Fusion-Spliced Near-Field Optical Fiber Probe Using Photonic Crystal Fiber for Nanoscale Thermometry Based on Fluorescence-Lifetime Measurement of Quantum Dots [O] . Takuro Fujii, Yoshihiro Taguchi, Toshiharu Saiki, 2011

机译：基于量子点荧光寿命测量的光子晶体光纤熔融拼接近场纳米探针。
7. Investigation of erbium dopant distribution in silica optical fibers with fluorescence-based measurements using a near-field scanning microscope [O] . orcid:0000-0003-4295-9730, orcid:0000-0002-1775-981X, Sidiroglou, F, 2014

机译：使用近场扫描显微镜研究基于荧光的二氧化硅光纤中的铒掺杂剂分布
8. Optical Measurements of Fluctuating Temperatures in a Supersonic Turbulent Flow Using One- and Two-Photon, Laser-Induced Fluorescence [R] . Gross, K. P., Mckenzie, R. L. 1984

机译：利用单光子和双光子，激光诱导荧光光学测量超音速湍流中的波动温度

Biosensing based on two-photon fluorescence measurements through optical fibers

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