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Optical measurement of the viscoelastic and biochemical responses of living cells to mechanical perturbation

机译：光学测量活细胞对机械扰动的粘弹性和生化反应

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We have developed an optical method for real-time monitoring of cellular motion in a natural environment with nanometer resolution. From the motion driven by small optical forces, we measured dynamic viscoelastic responses of living cells in the linear reversible region. Cytoplasmic gel-to-sol transition that was due to the disruption of the actin-filament framework was detected, and a linear release of Ca2+ from intracellular storage that was related to submicrometer cell deformation was observed. The method was shown to be a powerful tool for studying the natural response of cells to mechanical perturbation. (C) 1998 Optical Society of America. [References: 15]
机译：我们已经开发出一种光学方法，用于在自然环境中以纳米分辨率实时监视细胞运动。从小的光学力驱动的运动，我们测量了线性可逆区域中活细胞的动态粘弹性响应。检测到由于肌动蛋白丝构架的破坏而导致的细胞质凝胶向溶胶的转变，并且观察到Ca2 +从细胞内存储的线性释放与亚微米级细胞变形有关。该方法被证明是研究细胞对机械扰动的自然反应的有力工具。 （C）1998年美国眼镜学会。 [参考：15]

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