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首页> 外文期刊>Optics Letters >In vivo photoacoustic flow cytometry for monitoring of circulating single cancer cells and contrast agents
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In vivo photoacoustic flow cytometry for monitoring of circulating single cancer cells and contrast agents

机译：体内光声流式细胞术用于监测循环中的单个癌细胞和造影剂

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摘要

A new photoacoustic flow cytometry was developed for real-time detection of circulating cells, nanoparticles, and contrast agents in vivo. Its capability, integrated with photothermal and optical clearing methods, was demonstrated using a near-infrared tunable laser to characterize the in vivo kinetics of Indocyanine Green alone and single cancer cells labeled with gold nanorods and Indocyanine Green in the vasculature of the mouse ear. In vivo applications are discussed, including selective nanophotothermolysis of metastatic squamous cells, label-free detection of melanoma cells, study of pharmokinetics, and immune response to apoptotic and necrotic cells, with potential translation to humans. The threshold sensitivity is estimated as one cancer cell in the background of 10~(7) normal blood cells.
机译：开发了一种新的光声流式细胞术，用于实时检测体内循环细胞，纳米颗粒和造影剂。使用近红外可调谐激光器证明了其功能与光热和光学清除方法相结合，可表征单独的吲哚菁绿和小鼠耳血管中标记有金纳米棒和吲哚菁绿的单个癌细胞的体内动力学。讨论了体内应用，包括转移性鳞状细胞的选择性纳米光热解，黑素瘤细胞的无标记检测，药代动力学研究以及对凋亡和坏死细胞的免疫反应，并可能翻译为人类。阈值敏感性估计为在10〜（7）个正常血细胞的背景中有一个癌细胞。

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