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Simple time-domain optical method for estimating the depth and concentration of a fluorescent inclusion in a turbid medium

机译:一种简单的时域光学方法,用于估算混浊介质中荧光夹杂物的深度和浓度

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摘要

A simple time-domain optical method for estimating the depth and concentration of fluorescent inclusions in turbid media is described. We demonstrate direct depth estimation of a localized fluorescent object from the temporal position of the temporal point-spread function maximum. The depth estimation permits recovery of the fluorophore concentration, both of which are essential quantities for optical molecular imaging studies. Since the maximum is independent of the fluorophore concentration, excitation laser power, detector gain, and other system-dependent factors, this method ensures a robust and efficient approach.
机译:描述了一种简单的时域光学方法,用于估算混浊介质中荧光夹杂物的深度和浓度。我们演示了从时间点扩展函数最大值的时间位置对局部荧光对象的直接深度估计。深度估计可以恢复荧光团的浓度,这两个都是光学分子成像研究的基本要求。由于最大值与荧光团浓度,激发激光功率,检测器增益和其他系统相关因素无关,因此该方法可确保稳健而有效的方法。

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