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首页> 外文期刊>Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics >Pediatric mucosa-associated lymphoid tissue (MALT) lymphoma of lip: a case report and literature review.
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Pediatric mucosa-associated lymphoid tissue (MALT) lymphoma of lip: a case report and literature review.

机译：小儿口腔黏膜相关淋巴样组织（MALT）淋巴瘤：病例报告及文献复习。

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摘要

Mucosa-associated lymphoid tissue (MALT) lymphoma is listed in the new World Health Organization classification as extranodal marginal zone B-cell lymphoma of MALT. Most cases occur predominantly in adults and are rare in children or adolescents. We report, with a review of earlier literature, a MALT lymphoma of the lower lip in a 7-year-old immunocompetent child. The patient had a sessile, indurated, and firm mass on the lower lip without regional lymphadenopathy. Microscopically, dense lymphoid cell infiltrates composed of small- to medium-sized centrocyte-like cells and plasmacytoid cells infiltrating around scattered reactive germinal centers were observed, with formation of typical lymphoepithelial lesions. Immunohistochemical staining demonstrated positivity of atypical lymphoid cells for CD20, CD43, CD79a, and Bcl-2 and negativity for CD3, CD5, CD10, CD23, Ki-1, Bcl-10, and ALK. Cytoplasmic kappa light chain restriction was demonstrated. We conclude that this case represents the youngest patientwith a MALT lymphoma of the lip.
机译：粘膜相关淋巴样组织（MALT）淋巴瘤在新的世界卫生组织分类中被列为MALT的结外边缘区B细胞淋巴瘤。大多数病例主要发生在成年人中，在儿童或青少年中很少见。我们报告，通过对早期文献的回顾，在一个7岁免疫能力强的儿童中，下唇的MALT淋巴瘤。该患者下唇无梗，硬结且结实，无区域淋巴结肿大。在显微镜下，观察到由小到中型的中心细胞样细胞和浆细胞样细胞组成的致密淋巴样细胞浸润浸润在分散的反应生发中心周围，形成了典型的淋巴上皮病变。免疫组织化学染色显示非典型淋巴样细胞对CD20，CD43，CD79a和Bcl-2呈阳性，对CD3，CD5，CD10，CD23，Ki-1，Bcl-10和ALK呈阴性。证明了细胞质κ轻链限制。我们得出的结论是，该病例代表了唇部MALT淋巴瘤的最年轻患者。

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