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首页> 外文期刊>Oral oncology >Association of pretreatment thrombocytosis with disease progression and survival in oral squamous cell carcinoma.
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Association of pretreatment thrombocytosis with disease progression and survival in oral squamous cell carcinoma.

机译：口腔鳞状细胞癌中预处理血小板增多与疾病进展和生存的关系。

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The objective of this study was to review the prevalence and prognostic impact of pretreatment thrombocytosis in patients with oral squamous cell carcinoma (OSCC). Medical records of 253 patients with OSCC were retrospectively reviewed. The relationship between the platelet count, TNM stage, histologic differentiation, recurrence rate, metastasis, and survival were analyzed. Pretreatment thrombocytosis was found in 61 (24.1%) of 253 patients and was associated with aggressive tumour growth (p=0.015), lymph node metastasis (p=0.009), and distant metastasis (p=0.001). Association with tumour recurrence fell just short of statistical significance (p=0.058). Patients with preoperative thrombocytosis had a poorer survival than those with normal platelet counts (p=0.004). Multivariate analysis using Cox's proportional hazards model indicated that thrombocytosis was an independent predictor of shorter survival (RR 2.48, 95% CI 1.30- 4.73, p=0.006).
机译：这项研究的目的是审查在口腔鳞状细胞癌（OSCC）患者中治疗性血小板增多症的患病率和预后影响。回顾性分析253例OSCC患者的病历。分析了血小板计数，TNM分期，组织学分化，复发率，转移和生存之间的关系。 253名患者中有61名（24.1％）发现了治疗前的血小板增多症，与肿瘤的侵袭性生长（p = 0.015），淋巴结转移（p = 0.009）和远处转移（p = 0.001）有关。与肿瘤复发的关联仅略低于统计学意义（p = 0.058）。术前血小板增多症患者的生存率较血小板计数正常的患者差（p = 0.004）。使用Cox比例风险模型进行的多变量分析表明，血小板增多是生存期较短的独立预测因子（RR 2.48，95％CI 1.30- 4.73，p = 0.006）。

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