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首页> 外文期刊>Oral diseases >Neuropeptides in saliva of subjects with burning mouth syndrome: a pilot study.
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Neuropeptides in saliva of subjects with burning mouth syndrome: a pilot study.

机译：口腔灼热症患者唾液中的神经肽：一项初步研究。

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OBJECTIVE: A neuropathic basis has been suggested for burning mouth syndrome (BMS) and an altered concentration of neuropeptides has been reported in lingual oral mucosa and saliva in this disease. The aims of this study were to compare the levels of nerve growth factor (NGF), substance P (SP) and degranulation products from mast cells and neutrophils in the saliva of BMS subjects with those of control subjects. MATERIAL AND METHODS: Salivary flow rate, protein concentration, NGF peptide and mRNA, SP, mast cells tryptase, neutrophil myeloperoxidase and calprotectin were analyzed in saliva of 20 BMS subjects and of 20 age- and gender-matched healthy subjects. RESULTS AND CONCLUSIONS: NGF peptide and tryptase activity were shown to be significantly and persistently higher in saliva of BMS subjects, with respect to control values. Conversely the salivary levels of SP were shown to be significantly lower, while neutrophil markers didn't show any change. We conclude that the neuropathic origin of the disease is confirmed at salivary level. Furthermore, the higher tryptase activity indicates a possible involvement of mast cells. The salivary neuropeptide concentration in BMS subjects, together with mast cell derived compounds, could be useful biomarkers for diagnosis and monitoring of this disease.
机译：目的：已表明该病可归因于烧嘴综合征（BMS）的神经病理学基础，并且据报道该病的口腔舌黏膜和唾液中神经肽浓度发生变化。这项研究的目的是比较BMS受试者唾液中肥大细胞和嗜中性粒细胞的神经生长因子（NGF），P物质（SP）和脱颗粒产物的水平，以及对照受试者的唾液中的含量。材料与方法：分析了20名BMS受试者以及20名年龄和性别相匹配的健康受试者唾液中的唾液流速，蛋白质浓度，NGF肽和mRNA，SP，肥大细胞类胰蛋白酶，中性粒细胞髓过氧化物酶和钙卫蛋白。结果与结论：BMS受试者的唾液中NGF肽和类胰蛋白酶活性相对于对照值显着且持续较高。相反，唾液中SP的水平明显降低，而中性粒细胞标志物未显示任何变化。我们得出的结论是，该疾病的神经性起源已在唾液水平得到证实。此外，较高的类胰蛋白酶活性表明肥大细胞可能参与其中。 BMS受试者中唾液神经肽的浓度以及肥大细胞衍生的化合物可能是诊断和监测该病的有用生物标志物。

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