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首页> 外文期刊>Oral diseases >Immunoexpression of MMPs-1, -2, and -9 in ameloblastoma and odontogenic adenomatoid tumor.
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Immunoexpression of MMPs-1, -2, and -9 in ameloblastoma and odontogenic adenomatoid tumor.

机译：MMPs-1，-2和-9在成纤维细胞瘤和牙源性腺瘤样肿瘤中的免疫表达。

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OBJECTIVE: The aim of this study was to evaluate and compare the expression of metalloproteinases-1, -2, and -9 in solid ameloblastoma and adenomatoid odontogenic tumor. METHODS: A total of 20 cases of solid ameloblastoma and 10 cases of adenomatoid odontogenic tumors were selected and immunohistochemically assessed. Metalloproteinases-1, -2, and -9 immunoexpression and their distribution pattern were noted and semiquantitatively scored. The scores obtained were statistically analyzed. RESULTS: Matrix metalloproteinase (MMP)-1 showed a predominant expression in both tumors and was found in stroma and parenchyma. For MMP-2, there was a varied expression, with 80% and 60% of immunoreactive tumor cells in ameloblastoma and adenomatoid odontogenic tumor respectively. Regarding stromal cells, 65% of ameloblastomas and 80% of adenomatoid odontogenic tumors showed positivity. There was immunoexpression of the MMP-9 in parenchymal and stromal cells in all cases of both tumors analyzed. A statistically significant difference in the expression of MMP-1 in relation to the expression of MMP-2 and -9 in ameloblastomas (P < 0.001) was observed. CONCLUSION: The results suggest that these metalloproteinases are related to growth and progression of tumors analyzed, and particularly in ameloblastoma, its highest aggressiveness may be, in part, a result of the active participation of the stromal cells and their products, such as the MMPs studied.
机译：目的：本研究旨在评估和比较实体成纤维细胞瘤和腺瘤样成牙本质肿瘤中金属蛋白酶-1，-2和-9的表达。方法：选择20例实体成纤维细胞瘤和10例腺瘤样牙源性肿瘤并进行免疫组织化学评估。记录金属蛋白酶-1，-2和-9的免疫表达及其分布模式，并对它们进行半定量评分。对获得的分数进行统计分析。结果：基质金属蛋白酶（MMP）-1在两种肿瘤中均占主要表达，并在间质和实质中发现。对于MMP-2，在成纤维细胞瘤和腺瘤样牙源性肿瘤中分别有80％和60％的免疫反应性肿瘤细胞表达不同。关于基质细胞，成纤维细胞瘤和腺瘤样牙源性肿瘤中有65％呈阳性。在所分析的两种肿瘤的所有病例中，实质和基质细胞中均存在MMP-9的免疫表达。观察到成釉细胞瘤中MMP-1的表达相对于MMP-2和-9的表达具有统计学意义（P <0.001）。结论：这些结果表明这些金属蛋白酶与所分析的肿瘤的生长和进展有关，特别是在成釉细胞瘤中，其最高的侵袭性可能部分是由于基质细胞及其产物（例如MMPs）的积极参与所致。研究。

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