Bag-1 proteins in oral squamous cell carcinoma.

Wood J; Lee SS; Hague A

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Bag-1 proteins in oral squamous cell carcinoma.

机译：口腔鳞状细胞癌中的Bag-1蛋白。

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Bag-1 is an anti-apoptotic protein that exhibits altered expression in many malignancies, including oral squamous cell carcinoma. The bag-1 gene gives rise to different protein products with different subcellular localisations through alternative translational initiation sites. In oral squamous cell carcinoma, cytoplasmic expression has been associated with metastasis to regional lymph nodes and poor prognosis. In contrast, the longest Bag-1 isoform is nuclear and may regulate differentiation in oral epithelium. In this review, the functions of the three isoforms of Bag-1 expressed in oral epithelial cells are discussed in relation to their contribution to oral carcinogenesis.

机译：Bag-1是一种抗凋亡蛋白，在许多恶性肿瘤（包括口腔鳞状细胞癌）中表现出改变的表达。 bag-1基因通过其他翻译起始位点产生具有不同亚细胞定位的不同蛋白质产物。在口腔鳞状细胞癌中，细胞质表达与转移到局部淋巴结和预后不良有关。相反，最长的Bag-1亚型是核的，可能调节口腔上皮细胞的分化。在这篇综述中，讨论了在口腔上皮细胞中表达的Bag-1的三种同工型的功能及其与口腔癌发生的关系。

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《Oral oncology》 |2009年第2期|共9页
作者
Wood J; Lee SS; Hague A;
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正文语种 eng
中图分类肿瘤学;
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1. Bag-1 proteins in oral squamous cell carcinoma. [J] . Wood J, Lee SS, Hague A Oral oncology . 2009,第2期

机译：口腔鳞状细胞癌中的Bag-1蛋白。
2. Two members of the SIBLING family of proteins, DSPP and BSP, may predict the transition of oral epithelial dysplasia to oral squamous cell carcinoma. [J] . Ogbureke KU, Abdelsayed RA, Kushner H, Cancer: A Journal of the American Cancer Society . 2010,第7期

机译：SIBLING蛋白家族的两个成员DSPP和BSP可以预测口腔上皮发育异常向口腔鳞状细胞癌的转变。
3. Correlation of clinicopathological features with immunohistochemical expression of cell cycle regulatory proteins p16 and retinoblastoma: distinct association with keratinisation and differentiation in oral cavity squamous cell carcinoma. [J] . Muirhead DM, Hoffman HT, Robinson RA Journal of Clinical Pathology . 2006,第7期

机译：临床病理特征与细胞周期调控蛋白p16和视网膜母细胞瘤的免疫组织化学表达的关系：与口腔鳞状细胞癌的角化和分化明显相关。
4. The role of tumor markers and another clinico-laboratories results in prognosis of relapse oral squamous cell carcinoma. [C] . Yaremenko A.I., Manikhas G.M., Kutukova S.I., European Association of Cranio-Maxillo-Facial Surgery . 2010

机译：肿瘤标志物和另一种临床实验室的作用导致复发口腔鳞状细胞癌的预后。
5. Insulin-like growth factor binding protein-2: Contributions of the C-terminal domain to IGF binding and role in oral and oropharyngeal squamous cell carcinoma. [D] . Kibbey, Megan Marie. 2008

机译：胰岛素样生长因子结合蛋白2：C端结构域对IGF结合的贡献以及在口腔和口咽鳞状细胞癌中的作用。
6. Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 2: Human papillomavirus associated oral and oropharyngeal squamous cell carcinoma [O] . Liviu Feller, Neil H Wood, Razia AG Khammissa, 2010

机译：人乳头瘤病毒介导的癌变和与HPV相关的口腔和口咽鳞状细胞癌。第2部分：人乳头瘤病毒相关的口腔和口咽鳞状细胞癌
7. Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 2: Human papillomavirus associated oral and oropharyngeal squamous cell carcinoma [O] . Khammissa Razia AG, Wood Neil H, Feller Liviu, 2010

机译：人乳头瘤病毒介导的癌变和与HPV相关的口腔和口咽鳞状细胞癌。第2部分：人乳头瘤病毒相关的口腔和口咽鳞状细胞癌

Bag-1 proteins in oral squamous cell carcinoma.

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