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首页> 外文期刊>Oral oncology >Bisphosphonate related osteonecrosis of the jaw--manifestation in a microvascular iliac bone flap.
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Bisphosphonate related osteonecrosis of the jaw--manifestation in a microvascular iliac bone flap.

机译：双膦酸盐相关的颌骨坏死-表现在微血管骨瓣中。

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Bisphosphonate related osteonecrosis of the jaw (BRONJ) is a side effect that may emerge due to a long-term bisphosphonate therapy. Although the timely diagnosis and initiation of treatment are associated with good outcome results, extended cases require whole parts of the jaw to be resected. A possible treatment option is the bony reconstruction of the jaw using microvascular bone flaps. We report, for the first time, the development of a bisphosphonate related osteonecrosis in a microvascular iliac bone graft, a reconstruction that was performed following a partial mandibulectomy due to BRONJ stage III. The observation of BRONJ manifestation in an osseous microvascular transplant is a novel finding that sheds new light on current pathogenesis theories that surround this entity. Furthermore, it is hypothesized that BRONJ is able to progress to adjacent bone. In addition, bone reconstruction in patients suffering from BRONJ may be seen more critically.
机译：与双膦酸盐有关的颌骨坏死（BRONJ）是一种副作用，可能是由于长期使用双膦酸盐治疗所致。尽管及时诊断和开始治疗可带来良好的疗效，但扩大病例需要切除整个颌骨。一种可能的治疗选择是使用微血管骨瓣进行颌骨骨重建。我们首次报道了在微血管骨移植物中双膦酸盐相关的骨坏死的发展，该重建是由于BRONJ III期部分下颌骨切除术后进行的。骨微血管移植中BRONJ表现的观察是一个新颖的发现，为围绕该实体的当前发病机理理论提供了新的启示。此外，假设BRONJ能够前进到相邻的骨骼。此外，对于BRONJ患者的骨重建可能更为关键。

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