Efficacy and safety of medical ozone (O(3)) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: Preliminary results of a phase I-II study.

Ripamonti CI; Cislaghi E; Mariani L; Maniezzo M

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Efficacy and safety of medical ozone (O(3)) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: Preliminary results of a phase I-II study.

机译：在用双膦酸盐治疗的骨转移患者中，油悬浮液中用于治疗颌骨坏死的医用臭氧（O（3））的功效和安全性：I-II期研究的初步结果。

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Osteonecrosis of the jaw (ONJ) is an adverse event that has been reported in patients receiving cancer treatment regimens, including bevacizumab, bisphosphonates, and denosumab. We performed a preliminary open label, prospective phase I-II study in patients treated with bisphosphonate to evaluate the treatment effect and tolerability of medical ozone (O(3)) delivered in an oil suspension on BONJ lesions

机译：颌骨坏死（ONJ）是一种不良事件，已在接受包括贝伐单抗，双膦酸盐和地诺单抗在内的癌症治疗方案的患者中报告。我们对双膦酸盐治疗的患者进行了初步的开放标签，前瞻性I-II期研究，以评估油悬液中递送的医用臭氧（O（3））对BONJ病变

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《Oral oncology》 |2011年第3期|共6页
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Ripamonti CI; Cislaghi E; Mariani L; Maniezzo M;
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中图分类耳鼻咽喉科学;
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1. Efficacy and safety of medical ozone (O(3)) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: Preliminary results of a phase I-II study. [J] . Ripamonti CI, Cislaghi E, Mariani L, Oral oncology . 2011,第3期

机译：在用双膦酸盐治疗的骨转移患者中，油悬浮液中用于治疗颌骨坏死的医用臭氧（O（3））的功效和安全性：I-II期研究的初步结果。
2. Osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: a retrospective study. [J] . Ibrahim T, Barbanti F, Giorgio-Marrano G, The oncologist . 2008,第3期

机译：双膦酸盐治疗骨转移患者的颌骨坏死：一项回顾性研究。
3. Application of preventive measures minimizes the occurrence of osteonecrosis of the jaw (ONJ) in bisphosphonate treated breast cancer patients with bone metastases [J] . C.Ripamonti, M.Maniezzo, E.Cislaghi, European Journal of Cancer Supplements . 2008,第7期

机译：采取预防措施可使双膦酸盐治疗的骨转移癌患者的颌骨坏死（ONJ）发生率降至最低
4. Analysis of bone activity of jaws using scintigraphy on patients before, during and after treatment with IV bisphosphonates: A retrospective study. [D] . Handoo, Nidhi Q. 2009

机译：使用闪烁闪烁照相术分析静脉注射双膦酸盐治疗前后患者颌骨的骨活动：一项回顾性研究。
5. Efficacy and tolerability of medical ozone gas insufflations in patients with osteonecrosis of the jaw treated with bisphosphonates—Preliminary data [O] . C.I. Ripamonti, M. Maniezzo, S. Boldini, 2012

机译：双膦酸盐治疗下颌骨坏死患者的医用臭氧充气效果和耐受性—初步数据
6. Efficacy and tolerability of medical ozone gas insufflations in patients with osteonecrosis of the jaw treated with bisphosphonates—Preliminary data Medical ozone gas insufflation in treating ONJ lesions [O] . Ripamonti C.I., Maniezzo M., Boldini S., 2012

机译：双膦酸盐治疗下颌骨坏死患者医用臭氧充气的疗效和耐受性—初步数据医用臭氧充气治疗ONJ病变

Efficacy and safety of medical ozone (O(3)) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: Preliminary results of a phase I-II study.

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