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首页> 外文期刊>Osteoarthritis and cartilage >Effects of removal of the acetabular labrum in a sheep hip model.
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Effects of removal of the acetabular labrum in a sheep hip model.

机译：在绵羊髋关节模型中去除髋臼唇的影响。

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OBJECTIVE: The aim of this study was to learn whether partial resection of the acetabular labrum would lead to degenerative arthritis in an ovine model. METHODS: A 2 cm segment of labrum was removed from one hip in 18 mature Swiss Alpine sheep and a sham procedure was performed on the opposite side. Animals were permitted ad lib activity until sacrifice at 6, 12 or 24 weeks. The hip joint was removed en bloc, and loaded with a force of one body weight, using a custom device designed to recreate a physiologic joint reaction force. While under load, the joint was plunge frozen, and then fixed by freeze substitution using aldehydes in methanol/acetone solvents. The entire joint was embedded in methacrylate and sectioned in a standardized frontal plane following the reaction force and including the femoral neck and the acetabular fossa. The sections were evaluated for concentricity and evidence of arthrosis. Six hip joints of three sheep with no surgical procedure were loaded with high or low loads and served as non-surgical controls. RESULTS: Degenerative changes were present in all surgical hips, but the changes were symmetrical and mild. In 16 of 18 hips, the labrum regenerated to the extent that dense fibrous scar extending from the surgically denuded origin filled the defect. CONCLUSION: Resection of the labrum does not cause rapid degeneration or altered stability of the sheep hip.
机译：目的：本研究的目的是了解部分切除髋臼唇是否会在绵羊模型中导致退行性关节炎。方法：从18头成熟的瑞士高山绵羊的一只髋中取出2 cm的唇部，在另一侧进行假手术。允许动物自由活动直至在第6、12或24周处死。使用定制的可重现生理关节反作用力的定制设备，将髋关节整体取出，并施加一个体重的力。在负载下，将接头骤冷，然后在甲醇/丙酮溶剂中使用醛进行冷冻取代固定。整个关节被埋入甲基丙烯酸酯中，并在反作用力作用下在标准化的额叶面中切开，包括股骨颈和髋臼窝。评估切片的同心度和关节病的证据。在不进行手术的情况下，对三只绵羊的六个髋关节施加高负荷或低负荷，并作为非手术对照。结果：所有手术髋均出现退行性改变，但改变是对称且轻度的。在18髋中的16髋中，唇唇再生到一定程度，致密的纤维性瘢痕从手术剥脱的起源开始延伸，填补了缺损。结论：切除唇唇不会引起绵羊髋关节快速变性或稳定性改变。

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