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首页> 外文期刊>Osteoarthritis and cartilage >The association of prevalent medial meniscal pathology with cartilage loss in the medial tibiofemoral compartment over a 2-year period.
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The association of prevalent medial meniscal pathology with cartilage loss in the medial tibiofemoral compartment over a 2-year period.

机译：在2年的时间里，内侧半月板病变普遍存在于内侧胫股骨腔室的软骨丧失中。

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OBJECTIVE: To investigate the association of different types of magnetic resonance imaging (MRI)-detected medial meniscal pathology with subregional cartilage loss in the medial tibiofemoral compartment. METHODS: A total of 152 women aged >or=40 years, with and without knee osteoarthritis (OA) were included in a longitudinal 24-month observational study. Spoiled gradient recalled acquisitions at steady state (SPGR) and T2-weighted fat-suppressed MRI sequences were acquired. Medial meniscal status of the anterior horn (AH), body, and posterior horn (PH) was graded at baseline: 0 (normal), 1 (intrasubstance meniscal signal changes), 2 (single tears), and 3 (complex tears/maceration). Cartilage segmentation was performed at baseline and 24-month follow-up in various tibiofemoral subregions using computation software. Multiple linear regression models were applied for the analysis with cartilage loss as the outcome. In a first model, the results were adjusted for age and body mass index (BMI). In a second model, the results were adjusted for age, BMI and medial meniscal extrusion. RESULTS: After adjusting for age, BMI, and medial meniscal extrusion, cartilage loss in the total medial tibia (MT) (0.04 mm, P=0.04) and the external medial tibia (eMT) (0.068 mm, P=0.04) increased significantly for compartments with grade 3 lesions. Cartilage loss in the total central medial femoral condyle (cMF) (0.071 mm, P=0.03) also increased significantly for compartments with grade 2 lesions. Cartilage loss at the eMT was significantly related to tears of the PH (0.074 mm; P=0.03). Cartilage loss was not significantly increased for compartments with grade 1 lesions. CONCLUSION: The protective function of the meniscus appears to be preserved in the presence of intrasubstance meniscal signal changes. Prevalent single tears and meniscal maceration were found to be associated with increased cartilage loss in the same compartment, especially at the PH.
机译：目的：探讨不同类型的磁共振成像（MRI）检测到的内侧半月板病理与内侧胫股间隔中子区域软骨损失的关系。方法：一项为期24个月的纵向观察性研究共纳入152名年龄≥40岁的女性，有无膝关节骨关节炎（OA）。稳定状态（SPGR）的变差梯度记忆采集和T2加权脂肪抑制MRI序列均已获得。前角（AH），身体和后角（PH）的内侧半月板状态在基线分级：0（正常），1（实质性半月板信号变化），2（单眼泪）和3（复杂眼泪/浸渍） ）。使用计算软件在各个胫股次区域的基线和24个月随访中进行软骨分割。应用多个线性回归模型进行软骨损失分析。在第一个模型中，针对年龄和体重指数（BMI）调整了结果。在第二个模型中，针对年龄，BMI和半月板内侧挤压对结果进行了调整。结果：在调整了年龄，BMI和内侧半月板挤压后，总内侧胫骨（MT）（0.04 mm，P = 0.04）和外侧内侧胫骨（eMT）（0.068 mm，P = 0.04）的软骨损失显着增加适用于具有3级病变的隔室。对于有2级病变的隔室，整个中央股内侧con（cMF）（0.071 mm，P = 0.03）的软骨损失也显着增加。 eMT的软骨损失与PH的撕裂显着相关（0.074毫米; P = 0.03）。具有1级病变的隔室的软骨损失没有明显增加。结论：在存在物质内半月板信号变化的情况下，半月板的保护功能似乎得以保留。发现普遍的单眼泪和半月板浸软与同一腔室中软骨损失增加有关，尤其是在PH处。

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