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首页> 外文期刊>Osteoarthritis and cartilage >Long-term and resegmentation precision of quantitative cartilage MR imaging (qMRI).
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Long-term and resegmentation precision of quantitative cartilage MR imaging (qMRI).

机译：定量和定量软骨MR成像（qMRI）的长期和细分精度。

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OBJECTIVE: Follow up of osteoarthritis (OA) and evaluation of structure modifying OA drugs require longitudinal data on cartilage structure. The aim of this study was to analyse the long term and resegmentation precision of quantitative cartilage analysis with magnetic resonance imaging (qMRI) in vivo, and to relate precision errors to the estimated cartilage loss in OA. METHOD: Sagittal MR images of the knee were obtained in 14 individuals, four datasets being acquired in a first imaging session. In 12 subjects, two further datasets were acquired over the next months. Image analysis was performed in the same session for image data obtained under short-term and long-term imaging conditions, and in three different sessions (months apart) for the first data set (resegmentation precision). RESULTS: Long-term precision errors ranged from 1.4% (total knee) to 3.9% (total femur) for cartilage volume and thickness and were only marginally higher than those under short term conditions. In the medial tibia, theerror was 84 mm(3) compared with an estimated loss of >1,200 mm(3) in varus OA. Precision errors for resegmentation were somewhat higher, but considerably smaller than the intersubject variability. CONCLUSIONS: Scanner drift and changes in imaging or patient conditions appear not to represent a critical problem in quantitative cartilage analysis with magnetic resonance imaging (qMRI). In longitudinal studies, image analysis of sequential data should be performed within the same post-processing session. Under these conditions, qMRI promises to be a very powerful method to assess structural change of cartilage in OA.
机译：目的：对骨关节炎（OA）进行随访并评估结构修饰OA药物需要关于软骨结构的纵向数据。这项研究的目的是分析体内磁共振成像（qMRI）定量软骨分析的长期和细分精度，并将精度误差与OA中估计的软骨损失联系起来。方法：在14个人中获得了膝关节的矢状MR图像，在第一次成像过程中获取了四个数据集。在接下来的几个月中，在12位受试者中，又获得了两个数据集。对于在短期和长期成像条件下获得的图像数据，在同一会话中执行了图像分析，对于第一个数据集（细分精度），在三个不同的会话中（相隔数月）执行了图像分析。结果：软骨体积和厚度的长期精确度误差在1.4％（总膝部）至3.9％（股骨总部）之间，仅略高于短期条件下的误差。在胫骨内侧，该误差为84 mm（3），而内翻OA的估计损失为1200 mm（3）以上。细分的精度误差较高，但比对象间的可变性小得多。结论：扫描仪漂移和成像或患者状况的变化似乎并不代表磁共振成像（qMRI）定量软骨分析中的关键问题。在纵向研究中，应在同一后处理会话中对顺序数据进行图像分析。在这种情况下，qMRI有望成为评估OA软骨结构变化的非常有效的方法。

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