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首页> 外文期刊>Osteoarthritis and cartilage >Effect of fatty acids on bone marrow lesions and knee cartilage in healthy, middle-aged subjects without clinical knee osteoarthritis.
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Effect of fatty acids on bone marrow lesions and knee cartilage in healthy, middle-aged subjects without clinical knee osteoarthritis.

机译:脂肪酸对健康的中年受试者(无临床膝关节骨关节炎)的骨髓病变和膝软骨的影响。

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OBJECTIVE: There is evidence that omega-3 polyunsaturated fatty acids alleviate the progression of osteoarthritis (OA). However, little work has been done to investigate the effect of fatty acids on bone marrow lesions and knee cartilage in healthy subjects. We examined this in a cohort of healthy middle-aged subjects without clinical knee OA. METHODS: Two hundred and ninety-three healthy adults without knee pain or injury were recruited from an existing community-based cohort. Intakes of fatty acids and food sources of these were estimated from a food frequency questionnaire at baseline. Tibial cartilage volume, tibial plateau bone area, tibiofemoral cartilage defects and bone marrow lesions were assessed approximately 10 years later using magnetic resonance imaging. RESULTS: In multivariate analyses, higher intakes of monounsaturated fatty acids (OR=2.14, 95% CI 1.04-4.39, P=0.04), total (OR=1.77, 95% CI 1.13-2.77, P=0.01) and n-6 polyunsaturated fatty acids (OR=1.69, 95% CI 1.10-2.61, P=0.02) were associated with an increased risk of bone marrow lesions. Intake of fatty acids was not significantly associated with cartilage volume or cartilage defects. CONCLUSION: These findings support the dietary recommendation towards a shift to foods rich in n-3 polyunsaturated fatty acids in order to maintain an optimal balance between dietary n-3 and n-6 polyunsaturated fatty acids, which is also important in the prevention of atherosclerosis. Although our findings will need to be confirmed in longitudinal studies, they suggest the potential of fatty acids to adversely effect the knee joint.
机译:目的:有证据表明,omega-3多不饱和脂肪酸可减轻骨关节炎(OA)的发展。然而,很少有工作来研究脂肪酸对健康受试者骨髓损伤和膝软骨的影响。我们在没有临床膝骨关节炎的健康中年受试者队列中对此进行了检查。方法:从一个现有的社区队列中招募了293名没有膝盖疼痛或受伤的健康成年人。基线时从食物频率调查表估算了脂肪酸的摄入量和这些食物的食物来源。大约10年后,使用磁共振成像技术评估了胫骨软骨体积,胫骨平台骨面积,胫股软骨缺损和骨髓病变。结果:在多元分析中,单不饱和脂肪酸的摄入量较高(OR = 2.14,95%CI 1.04-4.39,P = 0.04),总摄入量(OR = 1.77,95%CI 1.13-2.77,P = 0.01)和n-6多不饱和脂肪酸(OR = 1.69,95%CI 1.10-2.61,P = 0.02)与骨髓病变的风险增加有关。脂肪酸的摄入与软骨体积或软骨缺损没有明显关系。结论:这些发现支持饮食推荐向富含n-3多不饱和脂肪酸的食物转变,以维持饮食中n-3和n-6多不饱和脂肪酸之间的最佳平衡,这在预防动脉粥样硬化中也很重要。尽管我们的发现需要在纵向研究中得到证实,但它们表明脂肪酸可能对膝关节产生不利影响。

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