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Osteoarthritis as a disease of mechanics

机译：骨关节炎是一种力学疾病

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摘要

Mechanics means relating to or caused by movement or physical forces. In this paper, I shall contend that osteoarthritis (OA) is almost always caused by increased physical forces causing damage to a joint. While examples of joint injury causing OA are numerous, I shall contend that most or almost all OA is caused in part by mechanically induced injury to joint tissues. Further, once joint pathology has developed, as is the case for almost all clinical OA, pathomechanics overwhelms all other factors in causing disease progression. Treatments which correct the pathomechanics have long lasting favorable effects on pain and joint function compared with treatments that suppress inflammation which have only temporary effects. I shall lastly contend that the mechanically induced joint injury leads to variable inflammatory responses but that the role of this inflammation in worsening structural damage in an already osteoarthritic joint has not yet been proven.
机译：力学是指与运动或物理力有关或由其引起的。在本文中，我将争辩说，骨关节炎（OA）几乎总是由增加的物理力导致的关节损伤引起的。尽管导致OA的关节损伤的例子很多，但我认为大多数或几乎所有OA的部分原因是对关节组织的机械性损伤。此外，一旦发展了关节病理学，就像几乎所有临床OA一样，病理力学将淹没导致疾病进展的所有其他因素。与仅具有暂时作用的抑制炎症的治疗相比，纠正病理力学的治疗对疼痛和关节功能具有长期持久的有利影响。我最后要说的是，机械诱发的关节损伤会导致多种炎症反应，但是这种炎症在已经骨关节炎的关节中破坏结构损伤的作用尚未得到证实。

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