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Chronic in vivo load alteration induces degenerative changes in the rat tibiofemoral joint

机译：慢性体内负荷改变引起大鼠胫股关节的退行性改变

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Objective: We investigated the relationship between the magnitude and duration of sustained compressive load alteration and the development of degenerative changes in the rat tibiofemoral joint. Methods: A varus loading device was attached to the left hind limb of mature rats to apply increased compression to the medial compartment and decreased compression to the lateral compartment of the tibiofemoral joint of either 0% or 100% body weight for 0, 6 or 20 weeks. Compartment-specific assessment of the tibial plateaus included biomechanical measures (articular cartilage aggregate modulus, permeability and Poisson's ratio, and subchondral bone modulus) and histological assessments (articular cartilage, calcified cartilage, and subchondral bone thicknesses, degenerative scoring parameters, and articular cartilage cellularity). Results: Increased compression in the medial compartment produced significant degenerative changes consistent with the development of osteoarthritis (OA) including a progressive decrease in cartilage aggregate modulus (43% and 77% at 6 and 20 weeks), diminished cellularity (38% and 51% at 6 and 20 weeks), and increased histological degeneration. At 20 weeks, medial compartment articular cartilage thickness decreased 30% while subchondral bone thickness increased 32% and subchondral bone modulus increased 99%. Decreased compression in the lateral compartment increased calcified cartilage thickness, diminished region-specific subchondral bone thickness and revealed trends for reduced cellularity and decreased articular cartilage thickness at 20 weeks. Conclusions: Altered chronic joint loading produced degenerative changes consistent with those observed clinically with the development of OA and may replicate the slow development of non-traumatic OA in which mechanical loads play a primary etiological role. ? 2012 Osteoarthritis Research Society International.
机译：目的：我们研究了持续压缩负荷改变的幅度和持续时间与大鼠胫股关节退行性变化发展之间的关系。方法：在成熟大鼠的左后肢上安装内翻物加载装置，以对0、6或20％体重的0％或100％的胫股关节内侧隔室施加增加的压力，对外侧股室施加减小的压力。周。专门针对胫骨平台的隔室评估包括生物力学测量（关节软骨聚集模量，渗透性和泊松比以及软骨下骨模量）和组织学评估（关节软骨，钙化软骨和软骨下骨厚度，退化性评分参数以及关节软骨细胞密度） ）。结果：内侧腔室压力的增加产生了明显的退行性改变，与骨关节炎（OA）的发展一致，包括软骨总模量的逐渐降低（在第6和20周时分别为43％和77％），细胞减少（38％和51％）在第6周和第20周），并增加了组织学变性。在20周时，内侧腔室软骨厚度减少30％，而软骨下骨厚度增加32％，软骨下骨模量增加99％。外侧腔室压力降低会增加钙化的软骨厚度，减少特定区域的软骨下骨的厚度，并显示出20周时细胞减少和关节软骨厚度降低的趋势。结论：慢性关节负荷改变产生的退行性变化与临床上随OA的发展而观察到的一致，并且可能复制了非创伤性OA的缓慢发展，其中机械负荷起主要病因作用。 ？ 2012年国际骨关节炎研究学会。

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