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首页> 外文期刊>Osteoarthritis and cartilage >The association of magnetic resonance imaging (MRI)-detected structural pathology of the knee with crepitus in a population-based cohort with knee pain: The MoDEKO study
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The association of magnetic resonance imaging (MRI)-detected structural pathology of the knee with crepitus in a population-based cohort with knee pain: The MoDEKO study

机译：MoDEKO研究表明，在以人群为基础的队列研究中，磁共振成像（MRI）检测到的膝关节结构病理与体的关系

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Osteoarthritis (OA) is the most common arthropathy of the knee joint. 1. Symptoms reported by patients and signs noted during physical examination guide clinicians in identifying subjects with knee OA. 2-4.Pain is one of the most important symptoms reported by subjects with knee OA. 2,3. Although very common, pain is a non-specific symptom, related to pathology in several structures within the knee joint, and includes synovitis. 5, subchondral bone marrow lesions. 6, and joint effusion. 7. Further, pain is a subjective symptom that cannot be directly measured or assessed during physical examination. Crepitus or crepitation in association with arthritis is defined as a crackling or grinding sound on joint movement with a sensation in the joint. Crepitus may occur with or without pain and is a common finding during physical examination in subjects with knee OA. 2-4,8,9.It is not known whether crepitus is related to pathology in various structures within the knee. The aim of our study was to determine the cross-sectional associations of structural pathologies within the knee with crepitus in a population-based cohort with knee pain, using magnetic resonance imaging (MRI).Subjects with knee pain were recruited as a random population sample, with crepitus assessed in each compartment of the knee using a validated and standardized approach during physical examination. 10. MRI of the knee was performed to assess cartilage morphology, meniscal morphology, osteophytes, cruciate ligaments, and collateral ligaments. For both compartment-specific and whole-knee analyses, a multiple logistic regression analysis was performed to assess the associations of MRI-detected structural pathology with crepitus, adjusting for potential confounders. Variables were selected by backwards elimination within each compartment and in the overall knee models, and only statistically significant variables remained in the selected models; remaining variables in these models are adjusted for each other. An increased risk for compartment-specific crepitus was associated with osteophytes at the patellofemoral (PF) and lateral tibiofemoral (LTF) joints. Crepitus was associated with osteophytes and medial collateral ligament (MCL) pathology at the medial tibiofemoral (MTF) compartment, but cartilage damage was negatively associated with crepitus at this compartment. In the selected whole-knee model, only meniscal tears were associated with an increased risk for general crepitus. Thus, it seems that crepitus may be associated with pathology in several internal structures.
机译：骨关节炎（OA）是最常见的膝关节关节炎。 1.患者报告的症状和体格检查期间发现的体征可指导临床医生确定膝关节炎。 2-4。疼痛是膝关节炎患者报告的最重要症状之一。 2，3。尽管很常见，但疼痛是一种非特异性症状，与膝关节内多个结构的病理相关，包括滑膜炎。 5，软骨下骨髓病变。 6，关节积液。 7.此外，疼痛是一种主观症状，无法在身体检查期间直接测量或评估。与关节炎有关的脆性或爆裂声被定义为关节运动时发出的crack啪声或打磨声，并在关节中产生感觉。膝痛可在有或没有疼痛的情况下发生，并且在膝关节炎患者的体格检查中是常见现象。 2-4、8、9。尚不知道与膝内各种结构的病理是否有关。本研究的目的是使用磁共振成像（MRI）方法确定以人群为基础的膝关节疼痛队列中膝部与肌的结构病理学的横断面关联。 ，在身体检查过程中使用经过验证和标准化的方法评估膝盖的每个隔间的。 10.进行了膝部MRI检查，以评估软骨的形态，半月板的形态，骨赘，十字韧带和侧副韧带。对于特定于隔室的分析和全膝分析，均进行了多重逻辑回归分析，以评估MRI检测到的结构病理与的相关性，并调整潜在的混杂因素。通过在每个隔间和整个膝关节模型中的向后消除来选择变量，并且所选模型中仅保留统计上显着的变量;这些模型中的其余变量会相互调整。 compartment股（PF）和胫股外侧（LTF）关节的骨赘与房室特异性牙龈的风险增加有关。 crepitus与胫骨股内侧（MTF）隔室的骨赘和内侧副韧带（MCL）病理相关，但软骨损害与该隔室的crepitus负相关。在选定的全膝关节模型中，仅半月板撕裂与一般性pit的风险增加相关。因此，似乎在几个内部结构中，快感可能与病理有关。

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