Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis

Bradley E. W.; Carpio L. R.; McGee-Lawrence M. E.; Becerra C. Castillejo; Amanatullah D. F.; Ta L. E.; Otero M.; Goldring M. B.; Kakar S.; Westendorf J. J.

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Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis

机译：Phlpp1促进创伤后骨关节炎，并由人类骨关节炎中的炎症和启动子去甲基化诱导

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Objective: Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability. OA is characterized by articular chondrocyte deterioration, subchondral bone changes and debilitating pain. One strategy to promote cartilage regeneration and repair is to accelerate proliferation and matrix production of articular chondrocytes. We previously reported that the protein phosphatase Phlpp1 controls chondrocyte differentiation by regulating the activities of anabolic kinases. Here we examined the role of Phlpp1 in OA progression in a murine model. We also assessed PHLPP1 expression and promoter methylation.

机译：目的：骨关节炎（OA）是最常见的关节炎形式，也是导致残疾的主要原因。 OA的特征是关节软骨细胞退化，软骨下骨变化和使人衰弱的疼痛。促进软骨再生和修复的一种策略是加速关节软骨细胞的增殖和基质产生。我们以前报道过，蛋白磷酸酶Phlpp1通过调节合成代谢激酶的活性来控制软骨细胞的分化。在这里，我们研究了在小鼠模型中Phlpp1在OA进展中的作用。我们还评估了PHLPP1表达和启动子甲基化。

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《Osteoarthritis and cartilage》 |2016年第6期|共8页
作者
Bradley E. W.; Carpio L. R.; McGee-Lawrence M. E.; Becerra C. Castillejo; Amanatullah D. F.; Ta L. E.; Otero M.; Goldring M. B.; Kakar S.; Westendorf J. J.;
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正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
DNA methylation; Articular cartilage; Il6; TNF alpha; Mechanical allodynia; DMM mouse model;

机译：DNA甲基化;关节软骨;Il6;TNFα;机械性异常性疼痛;DMM小鼠模型;

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专利

1. Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis [J] . Bradley E. W., Carpio L. R., McGee-Lawrence M. E., Osteoarthritis and cartilage . 2016,第6期

机译：Phlpp1促进创伤后骨关节炎，并由人类骨关节炎中的炎症和启动子去甲基化诱导
2. Casticin protects against IL-1 beta-induced inflammation in human osteoarthritis chondrocytes [J] . Mu Yiping, Hao Wei, Li Songbai European Journal of Pharmacology: An International Journal . 2019,第期

机译：Casticin在人骨关节炎中保护IL-1β诱导的炎症
3. Salidroside attenuates interleukin-1-induced inflammation in human osteoarthritis chondrocytes [J] . Zhang Yuan, Zhao Qing Journal of cellular biochemistry. . 2019,第2期

机译：Salidroside衰减白细胞介素-1诱导的人骨关节炎软骨细胞中的炎症
4. Post-traumatic osteoarthritis: The role of stress induced chondrocyte damage [C] . J.A. Martin, J. A. Buckwalte International Symposium on Mechanobiology of Cartilage and Chondrocyte . 2006

机译：创伤后骨关节炎：应激诱发的软骨细胞损伤的作用
5. Evaluation of impact injury as a model of experimentally induced post-traumatic osteoarthritis in the equine metacarpophalangeal joint. [D] . Rickey, Ellen J. 2011

机译：评价冲击损伤作为实验性马掌指关节关节创伤性骨关节炎的模型。
6. Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis [O] . Elizabeth W. Bradley, Lomeli R. Carpio, Meghan E. McGee-Lawrence, -1

机译：Phlpp1促进创伤后骨关节炎并由人类骨关节炎中的炎症和启动子去甲基化诱导
7. PHLPP1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis [O] . E.W. Bradley, L.R. Carpio, D.F. Amanatullah, 2016

机译：Phlpp1促进创伤后骨关节炎，并通过人骨关节炎的炎症和启动子去甲基化诱导

Phlpp1 facilitates post-traumatic osteoarthritis and is induced by inflammation and promoter demethylation in human osteoarthritis

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