Reciprocal activation of hypoxia-inducible factor (HIF)-2 alpha and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis

Lee M.; Won Y.; Shin Y.; Kim J. -H.; Chun J. -S.

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Reciprocal activation of hypoxia-inducible factor (HIF)-2 alpha and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis

机译：缺氧诱导因子（HIF）-2α和锌-ZIP8-MTF1轴的相互激活放大了骨关节炎中的分解代谢信号

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Objective: Hypoxia-inducible factor (HIF)-2 alpha and the zinc-ZIP8-MTF1 axis in chondrocytes serve as catabolic regulators of osteoarthritic cartilage destruction by regulating the expression of catabolic factor genes. We explored possible crosstalk between these signaling pathways and its biological significance in osteoarthritis (OA).

机译：目的：软骨细胞中的缺氧诱导因子（HIF）-2α和锌-ZIP8-MTF1轴通过调节分解代谢因子基因的表达，作为骨关节炎软骨破坏的分解代谢调节剂。我们探讨了这些信号通路与其在骨关节炎（OA）中的生物学意义之间的可能串扰。

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《Osteoarthritis and cartilage》 |2016年第1期|共12页
作者
Lee M.; Won Y.; Shin Y.; Kim J. -H.; Chun J. -S.;
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正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Osteoarthritis; Catabolic signaling; Hypoxia-inducible factor (HIF)-2 alpha; Zinc-ZIP8-MTF1 axis;

机译：骨关节炎;代谢信号;缺氧诱导因子（HIF）-2 alpha;ZIP-ZIP8-MTF1轴;

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1. Reciprocal activation of hypoxia-inducible factor (HIF)-2 alpha and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis [J] . Lee M., Won Y., Shin Y., Osteoarthritis and cartilage . 2016,第1期

机译：缺氧诱导因子（HIF）-2α和锌-ZIP8-MTF1轴的相互激活放大了骨关节炎中的分解代谢信号
2. Toll-like receptor activation and hypoxia use distinct signaling pathways to stabilize hypoxia-inducible factor 1alpha (HIF1A) and result in differential HIF1A-dependent gene expression. [J] . Jantsch J, Wiese M, Schodel J, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2011,第3期

机译：Toll样受体激活和缺氧使用独特的信号通路来稳定缺氧诱导因子1alpha（HIF1A），并导致差异的HIF1A依赖性基因表达。
3. Reciprocal regulation by hypoxia-inducible factor-2 alpha and the NAMPT-NAD(+)-SIRT axis in articular chondrocytes is involved in osteoarthritis [J] . Oh H., Kwak J. -S., Yang S., Osteoarthritis and cartilage . 2015,第12期

机译：缺氧诱导因子-2α和NAMPT-NAD（+）-SIRT轴在软骨细胞中的相互调节与骨关节炎有关
4. Hypoxia-inducible factor-1/spl alpha/ (HIF-1/spl alpha/) and photodynamic therapy [C] . Lin-Hung Wei, Chia-Hung Chou, Jen-Liang Su . 2004

机译：缺氧诱导因子-1 / spl alpha /（HIF-1 / spl alpha /）和光动力疗法
5. Hypoxia-inducible factor-1 alpha (HIF-1alpha) and its role in the hypoxic preconditioning and gene expression patterns in zebrafish ( Danio rerio) embryos. [D] . Mohamed, Amira F. 2007

机译：低氧诱导因子-1α（HIF-1alpha）及其在斑马鱼（Danio rerio）胚胎的低氧预处理和基因表达模式中的作用。
6. Long Non-Coding RNAs (lncRNAs) Tumor-Suppressive Role of lncRNA on Chromosome 8p12 (TSLNC8) Inhibits Tumor Metastasis and Promotes Apoptosis by Regulating Interleukin 6 (IL-6)/Signal Transducer and Activator of Transcription 3 (STAT3)/Hypoxia-Inducible Factor 1-alpha (HIF-1α) Signaling Pathway in Non-Small Cell Lung Cancer [O] . Hanli Fan, Jianbo Li, Jiwu Wang, 2019

机译：长非编码RNA（lncRNAs）lncRNA在染色体8p12（TSLNC8）上的肿瘤抑制作用通过调节白介素6（IL-6）/信号转导子和转录激活因子3（STAT3）/低氧诱导剂来抑制肿瘤转移并促进细胞凋亡。非小细胞肺癌中的因子1-alpha（HIF-1α）信号通路
7. Reciprocal activation of hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis [O] . Lee M., Won Y., Shin Y., 2016

机译：缺氧诱导因子（HIF）-2α和锌-ZIP8-MTF1轴的相互激活放大了骨关节炎中的分解代谢信号
8. Contribution of Hypoxia-Inducible Factor (HIF) -1 Alpha to Normal Mammary Gland Development and Mammary Tumorigenesis [R] . Seagroves, T. N. 2003

机译：缺氧诱导因子（HIF）-1α对正常乳腺发育和乳腺肿瘤发生的贡献

Reciprocal activation of hypoxia-inducible factor (HIF)-2 alpha and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis

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