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Effect of muscle weakness and joint inflammation on the onset and progression of osteoarthritis in the rabbit knee

机译：肌肉无力和关节发炎对兔膝骨关节炎发作和进展的影响

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Objectives: Interactions between mechanical and non-mechanical independent risk factors for the onset and progression of Osteoarthritis (OA) are poorly understood. Therefore, the goal of the present study was to investigate the invivo effects of muscle weakness, joint inflammation and the combination on the onset and progression of OA in a rabbit knee joint model. Materials and methods: Thirty 1-year-old female New Zealand White rabbits (average 5.7kg, range 4.8-6.6kg) were divided into four groups with one limb randomly assigned to be the experimental side: (1) surgical denervation of the vastus lateralis (VL) muscle; (2) muscle weakness induced by intramuscular injection of Botulinum toxin A (BTX-A); (3) intraarticular injection with Carrageenan to induce a transient inflammatory reaction; (4) combination of Carrageenan and BTX-A injection. After 90days, cartilage histology of the articular surfaces were microscopically analyzed using the Osteoarthritis Research Society International (OARSI) histology scoring system. Results: VL denervation resulted in significantly higher OARSI scores in the patellofemoral joint (group 1). BTX-A administration resulted in significant cartilage damage in all four compartments of the knee (group 2). Carrageenan did not cause significant cartilage damage. BTX-A combined with Carrageenan lead to severe cartilage damage in all four compartments. Conclusion: Muscle weakness lead to significant OA in the rabbit knee. A transient local inflammatory stimulus did not promote cartilage degradation nor did it enhance OA progression when combined with muscle weakness. These results are surprising and add to the literature the conclusion that acute inflammation is probably not an independent risk factor for OA in this rabbit model.
机译：目的：关于骨关节炎（OA）发病和进展的机械和非机械独立危险因素之间的相互作用了解甚少。因此，本研究的目的是研究兔膝关节模型中肌肉无力，关节发炎及其联合对OA发病和进展的体内作用。材料和方法：30只1岁的新西兰大白兔（平均5.7kg，范围4.8-6.6kg）分为四组，每只肢体随机分配为实验侧：（1）股神经外科手术去神经外侧肌（VL）; （2）肌肉注射肉毒杆菌毒素A（BTX-A）引起的肌肉无力; （3）关节内注射角叉菜胶引起短暂的炎症反应; （4）角叉菜胶和BTX-A注射液的组合。 90天后，使用国际骨关节炎研究协会（OARSI）组织学评分系统对关节表面的软骨组织学进行了显微镜分析。结果：VL失神经导致the股关节的OARSI评分明显升高（第1组）。 BTX-A给药在膝盖的所有四个腔室中均导致了严重的软骨损伤（第2组）。角叉菜胶没有引起明显的软骨损伤。 BTX-A与角叉菜胶联合使用会在所有四个隔室中严重破坏软骨。结论：肌无力导致兔膝关节明显OA。当与肌肉无力结合时，短暂的局部炎症刺激既不促进软骨退化也不促进OA进展。这些结果是令人惊讶的，并在文献中增加了急性炎症可能不是该兔模型中OA的独立危险因素的结论。

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