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首页> 外文期刊>Osteoarthritis and cartilage >Heritability assessment of cartilage metabolism. A twin study on circulating procollagen IIA N-terminal propeptide (PIIANP)
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Heritability assessment of cartilage metabolism. A twin study on circulating procollagen IIA N-terminal propeptide (PIIANP)

机译：软骨代谢的遗传力评估。循环前胶原IIA N末端前肽（PIIANP）的双胞胎研究

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Objective: The aim of this investigation was to estimate the heritability of circulating collagen IIA N-terminal propeptide (PIIANP) by studying mono- and dizygotic healthy twin pairs at different age and both genders. Design: 598 monozygotic (MZ) and dizygotic (DZ) twin individuals aged 18-59 years were recruited from the Danish Twin Registry. PIIANP was measured by competitive ELISA. The similarity of circulating PIIANP among MZ and DZ twins was assessed by intraclass correlations according to traits. The heritability was estimated by variance component analysis accounting for additive and dominant genetic factors as well as shared and non-shared environment but ignoring epistasis (genetic inter-locus interaction) and gene-environment interaction. Results: The intraclass correlation of PIIANP in MZ and DZ twins was 0.69 (0.60-0.76) and 0.46 (0.34-0.58) respectively indicating a significant genetic impact on PIIANP in serum. Additive genetic effects explained 45% (21-70%), shared environment 24% (7-53%) and non-shared environment 31% (24-39%) of the total variance. The heritability estimate did not differ across ages and between genders. Conclusions: The study shows that approximately 45% of the collagen IIA synthesis as assessed by the collagen IIA N-terminal propeptide in serum is attributable to genetic effectors while individual and shared environment account for 24% and 31% respectively. The heritability does not differ between genders or according to age.
机译：目的：本研究的目的是通过研究不同年龄和性别的单卵双胎和双卵双生健康双胞胎对循环胶原蛋白IIA N末端前肽（PIIANP）的遗传力。设计：从丹麦双胞胎登记处招募了年龄在18-59岁的598个单卵（MZ）和双卵（DZ）双胞胎个体。通过竞争性ELISA测量PIIANP。根据性状，通过类内相关性评估MZ和DZ双胞胎之间循环PIIANP的相似性。遗传力是通过方差成分分析估计的，这些因素考虑了加性和显性遗传因素以及共享和非共享环境，但忽略了上位性（基因位点间相互作用）和基因-环境相互作用。结果：MZ和DZ双胞胎中PIIANP的类内相关性分别为0.69（0.60-0.76）和0.46（0.34-0.58），表明对PIIANP血清有显着的遗传影响。可加遗传效应解释了总方差的45％（21-70％），共享环境24％（7-53％）和非共享环境31％（24-39％）。遗传力估计值在各个年龄段和性别之间均没有差异。结论：研究表明，血清中胶原蛋白IIA N末端前肽评估的胶原蛋白IIA合成中约有45％归因于遗传效应，而个体和共享环境分别占24％和31％。性别或年龄之间的遗传力没有差异。

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