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首页> 外文期刊>Osteoarthritis and cartilage >Templates of the cartilage layers of the patellofemoral joint and their use in the assessment of osteoarthritic cartilage damage.
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Templates of the cartilage layers of the patellofemoral joint and their use in the assessment of osteoarthritic cartilage damage.

机译：em股关节软骨层模板及其在评估骨关节炎软骨损伤中的用途。

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摘要

OBJECTIVE: To develop a methodology for generating templates that represent the normal human patellofemoral joint (PFJ) topography and cartilage thickness, based on a statistical average of healthy joints. Also, to determine the cartilage thickness in the PFJs of patients with osteoarthritis (OA) and develop a methodology for comparing an individual patient's thickness maps to the normal templates in order to identify regions that are most likely to represent loss of cartilage thickness. DESIGN: The patella and femur surfaces of 14 non-arthritic human knee joints were quantified using either stereophotogrammetry or magnetic resonance imaging. The surfaces were aligned, scaled, and averaged to create articular topography templates. Cartilage thicknesses were measured across the surfaces and averaged to create maps of normal cartilage thickness distribution. In vivo thickness maps of articular layers from 33 joints with OA were also generated, and difference maps were created depicting discrepancies between the patients' cartilage thickness maps and the normative template. RESULTS: In the normative template, the surface-wide mean+/-SD (maximum) of the cartilage thickness was 2.2+/-0.4mm (3.7mm) and 3.3+/-0.6mm (4.6mm) for the femur and patella, respectively. It was demonstrated that difference maps could be used to identify regions of thinner-than-normal cartilage in patients with OA. Patients were shown to have statistically greater regions of thin cartilage over their articular layers than the normal joints. On average, patients showed deficits in cartilage thickness in the lateral facet of the patella, in the anterior medial and lateral condyles, and in the lateral trochlea of the femur. CONCLUSIONS: This technique can be useful for in vivo clinical evaluation of cartilage thinning in the osteoarthritic patellofemoral joint.
机译：目的：根据健康关节的统计平均值，开发一种用于生成代表正常人human股关节（PFJ）地形和软骨厚度的模板的方法。同样，要确定骨关节炎（OA）患者的PFJ中的软骨厚度，并开发一种将单个患者的厚度图与正常模板进行比较的方法，以识别最有可能代表软骨厚度损失的区域。设计：使用立体摄影测量法或磁共振成像法对14个非关节炎性人膝关节的骨和股骨表面进行定量。将表面对齐，缩放和平均以创建关节形貌模板。测量整个表面的软骨厚度并取平均值，以创建正常软骨厚度分布图。还生成了来自33个OA关节的关节层的体内厚度图，并创建了差异图，描绘了患者的软骨厚度图与规范模板之间的差异。结果：在规范性模板中，股骨和骨的软骨厚度的全表面平均+/- SD（最大值）为2.2 +/- 0.4mm（3.7mm）和3.3 +/- 0.6mm（4.6mm），分别。结果表明，差异图可用于识别OA患者软骨比正常情况薄的区域。统计表明，与正常关节相比，患者的关节层薄软骨区域更大。平均而言，患者在showed骨外侧，前内侧和外侧con以及股骨外侧滑车中软骨厚度缺乏。结论：该技术可用于骨关节炎evaluation股关节软骨变薄的体内临床评估。

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