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首页> 外文期刊>Schizophrenia research >Prefrontal cognitive functions in stabilized first-episode patients with schizophrenia spectrum disorders: a dissociation between dorsolateral and orbitofrontal functioning.
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Prefrontal cognitive functions in stabilized first-episode patients with schizophrenia spectrum disorders: a dissociation between dorsolateral and orbitofrontal functioning.

机译：稳定的精神分裂症频谱疾病的首发患者的前额叶认知功能：背外侧和眶额功能之间的分离。

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摘要

Specific prefrontal cognitive impairments have been reported in first-episode and chronic schizophrenia. We sought to investigate potential impairments in specific prefrontal cortical cognitive functions among stabilized patients with a first-episode of schizophrenia. A sample of 80 individuals with a first-episode of schizophrenia spectrum disorders and 22 healthy volunteers underwent a neurocognitive battery assessing orbitofrontal (OFC) [The Iowa Gambling Task (GT)], and dorsolateral prefrontal (DLPFC) functions (WAIS III Backward digits, verbal fluency test (FAS), and Trail Making Test). Cognitive data were obtained following stabilization of acute psychotic symptoms. Clinical symptoms after six weeks of treatment were assessed by using the SAPS and SANS scales. While there were no significant group differences in overall scores and in the profile of progress of performance along periods on the GT, patient group showed a significant impairment when performing DLPFC tasks. Only FAS score was correlated to the severity of negative symptomatology. The OFC functions are unimpaired at the early phases of psychosis and in contrast there is a significant deficit in DLPFC functions in first-episode of schizophrenia.
机译：在第一季和慢性精神分裂症中已报道了特定的额前认知障碍。我们试图调查精神分裂症首发稳定患者中特定前额叶皮质认知功能的潜在损害。对80位首发精神分裂症谱系疾病的个体和22位健康志愿者进行了一次神经认知电池评估眶额（OFC）[爱荷华州赌博任务（GT）]和背外侧前额（DLPFC）功能（WAIS III后向数字，口语流利测试（FAS）和跟踪制作测试）。在急性精神病症状稳定后获得认知数据。使用SAPS和SANS量表评估治疗六周后的临床症状。虽然总体得分和整个GT期间的表现进展情况在组间没有显着差异，但患者组在执行DLPFC任务时表现出明显的损伤。只有FAS评分与阴性症状的严重程度相关。在精神病的早期阶段，OFC功能没有受到损害，相反，在精神分裂症的首发中DLPFC功能明显不足。

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