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首页> 外文期刊>Schizophrenia bulletin >Social cognition as a mediator variable between neurocognition and functional outcome in schizophrenia: empirical review and new results by structural equation modeling.
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Social cognition as a mediator variable between neurocognition and functional outcome in schizophrenia: empirical review and new results by structural equation modeling.

机译：社会认知是精神分裂症中神经认知与功能结果之间的中介变量：实证研究和结构方程模型的新结果。

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Cognitive impairments are currently regarded as important determinants of functional domains and are promising treatment goals in schizophrenia. Nevertheless, the exact nature of the interdependent relationship between neurocognition and social cognition as well as the relative contribution of each of these factors to adequate functioning remains unclear. The purpose of this article is to systematically review the findings and methodology of studies that have investigated social cognition as a mediator variable between neurocognitive performance and functional outcome in schizophrenia. Moreover, we carried out a study to evaluate this mediation hypothesis by the means of structural equation modeling in a large sample of 148 schizophrenia patients. The review comprised 15 studies. All but one study provided evidence for the mediating role of social cognition both in cross-sectional and in longitudinal designs. Other variables like motivation and social competence additionally mediated the relationship between social cognition and functional outcome. The mean effect size of the indirect effect was 0.20. However, social cognitive domains were differentially effective mediators. On average, 25% of the variance in functional outcome could be explained in the mediation model. The results of our own statistical analysis are in line with these conclusions: Social cognition mediated a significant indirect relationship between neurocognition and functional outcome. These results suggest that research should focus on differential mediation pathways. Future studies should also consider the interaction with other prognostic factors, additional mediators, and moderators in order to increase the predictive power and to target those factors relevant for optimizing therapy effects.
机译：认知障碍目前被认为是功能域的重要决定因素，在精神分裂症中有望成为治疗目标。然而，神经认知和社会认知之间相互依存关系的确切性质以及这些因素对适当功能的相对贡献尚不清楚。本文的目的是系统地审查研究社会认知作为精神分裂症患者神经认知表现和功能预后之间的中介变量的研究结果和方法。此外，我们进行了一项研究，通过结构方程模型对148位精神分裂症患者的大量样本进行评估，以评估这种调解假设。审查包括15项研究。除一项研究外，所有研究都为社会认知在横断面和纵向设计中的中介作用提供了证据。动机和社会能力等其他变量还介导了社会认知与功能结果之间的关系。间接效应的平均效应大小为0.20。但是，社会认知领域是差异有效的媒介。平均而言，可以在调解模型中解释功能结果差异的25％。我们自己的统计分析结果与以下结论一致：社会认知介导了神经认知与功能结果之间的显着间接关系。这些结果表明，研究应集中在不同的调解途径上。未来的研究还应考虑与其他预后因素，其他介体和调节剂的相互作用，以增加预测能力并针对那些与优化治疗效果相关的因素。

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