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首页> 外文期刊>Schizophrenia research >Specific brain structural abnormalities in first-episode schizophrenia. A comparative study with patients with schizophreniform disorder, non-schizophrenic non-affective psychoses and healthy volunteers.
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Specific brain structural abnormalities in first-episode schizophrenia. A comparative study with patients with schizophreniform disorder, non-schizophrenic non-affective psychoses and healthy volunteers.

机译：首发精神分裂症的特定脑结构异常。与精神分裂症样疾病，非精神分裂症非情感性精神病患者和健康志愿者的比较研究。

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Evidence so far indicates the consistent association between brain structural abnormalities and schizophrenia already present at the early phases of the illness. This study investigates the specificity of brain structural abnormalities in schizophrenia by using region-of-interest method of volumetric analysis in a heterogeneous sample of schizophrenia spectrum patients at their first break of the illness. 225 subjects, comprising 82 schizophrenia patients, 36 schizophreniform disorder patients and 24 patients with non-schizophrenic non-affective psychoses, and 83 healthy individuals underwent a magnetic resonance imaging brain scan. Quantitative brain morphometric variables were assessed: cortical CSF, lateral ventricle, total brain tissue, white matter and cortical and subcortical gray matter volumes. The contribution of sociodemographic, cognitive and clinical characteristics was controlled. Compared with controls, schizophrenia (P=0.017) and schizophreniform disorder (P=0.023) patients showed an increase in cortical CSF volume. Schizophrenia patients had also markedly enlarged lateral ventricle volume compared to controls (P=0.026). The patients with non-schizophrenic non-affective psychoses did not significantly differ in lateral ventricle and cortical CSF volumes from controls. Compared with controls, schizophrenia and schizophreniform disorder patients demonstrated a significant decrease in total brain tissue (-1.30% and -1.12% respectively). Thalamic volume was reduced (-3.84%) in schizophrenia patients compared to controls (P=0.040). Clinical and cognitive variables were not significantly related with morphological changes. The brain changes found in patients with a first episode of schizophrenia spectrum disorders are robustly associated with the diagnoses of schizophrenia and schizophreniform disorder and are independent of relevant intervening variables.
机译：迄今为止的证据表明，在疾病的早期阶段就已经存在脑结构异常和精神分裂症之间的一致性。这项研究通过使用异质性精神分裂症频谱患者样本中第一次疾病时使用体积分析的感兴趣区域方法，研究了精神分裂症脑结构异常的特异性。 225位受试者包括82位精神分裂症患者，36位精神分裂症样疾病患者和24位非精神分裂症非情感性精神病患者，并对83位健康个体进行了磁共振成像脑部扫描。评估了定量的大脑形态计量变量：皮质CSF，侧脑室，总脑组织，白质以及皮质和皮质下灰质体积。社会人口统计学，认知和临床特征的贡献得到控制。与对照组相比，精神分裂症（P = 0.017）和精神分裂症样疾病（P = 0.023）患者的皮质CSF量增加。与对照相比，精神分裂症患者的侧脑室容量也明显增加（P = 0.026）。非精神分裂症非情感性精神病患者的侧脑室和皮层脑脊液体积与对照组无显着差异。与对照组相比，精神分裂症和精神分裂症患者的总脑组织明显减少（分别为-1.30％和-1.12％）。与对照相比，精神分裂症患者的丘脑容量减少了（-3.84％）（P = 0.040）。临床和认知变量与形态变化无显着相关。首发精神分裂症谱系障碍患者的脑部变化与精神分裂症和精神分裂症样疾病的诊断密切相关，并且与相关的干预变量无关。

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